Preparation method of high-concentration long-acting doxycycline injection adopting low organic solvent
A doxycycline and organic solvent technology, applied in the field of high-concentration doxycycline injection, can solve the problems of high use of organic solvents and high product costs, and achieve the effects of stable quality, high concentration, and high cost
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Embodiment 1
[0033] Example 1: Preparation of 10% doxycycline injection:
[0034] Take 5gPVPK 30 Dissolve in 50ml of 60℃ water for injection, add 0.6g sodium metabisulfite and stir until completely dissolved, add 10g magnesium chloride, stir until completely dissolved, slowly add 10g doxycycline, stir at 15℃ until mixed, add 10g ethanol and stir until completely dissolved , Then adjust the pH to 8.5 with ethanolamine, dilute the volume to 100ml with water for injection, filter potting, 10ml / piece, sterilize, and package it.
Embodiment 2
[0035] Example 2: Preparation of 10% doxycycline injection;
[0036] Take 5gPVPK 30 Dissolve in 50ml of 60℃ water for injection, add 0.6g sodium metabisulfite and stir until completely dissolved, add 10g magnesium chloride, stir until completely dissolved, slowly add 10g doxycycline, stir at 15℃ until mixed, add 10g ethanol and stir until completely dissolved , Then adjust the pH to 7.5 with ethanolamine, dilute the volume to 100ml with water for injection, filter potting, 10ml / piece, sterilize, and pack it.
Embodiment 3
[0037] Example 3: Preparation of 10% doxycycline injection;
[0038] Take 5gPVPK 30 Dissolve in 50ml of 60℃ water for injection, add 0.6g sodium metabisulfite and stir until completely dissolved, add 10g magnesium chloride, stir until completely dissolved, slowly add 10g doxycycline, stir at 15℃ until mixed, add 10g ethanol and stir until completely dissolved , Then adjust the pH to 9.0 with ethanolamine, dilute the volume to 100ml with water for injection, filter potting, 10ml / piece, sterilize, and pack it.
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