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Application of medicinal preparation for preparing medicine used for treating chloasma disease

A pharmaceutical preparation, a technology for chloasma, applied in skin diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as high price

Inactive Publication Date: 2010-05-05
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the drugs that have been approved for chloasma include Jingtian Quban Capsules, Tiaojing Quban Capsules, Huayu Quban Capsules, Qixuehe Capsules, Shugan Granules, etc. The prescription drugs mainly include Rhodiola, Angelica, Radix Paeoniae Alba, Safflower, astragalus, rehmannia, etc., but the price is relatively expensive

Method used

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  • Application of medicinal preparation for preparing medicine used for treating chloasma disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1 Pharmacodynamics test

[0011] 1.1 Summary

[0012] The above-mentioned extract was given to chloasma model mice by intragastric administration of 2.83, 5.67g, 11.34g crude drug / kg, once a day for 30 consecutive days, and blood was taken from the mouse orbit after the last administration to determine the viscosity of the whole blood After the mice were sacrificed, the back skin was taken to observe the pathomorphology of skin melanocytes. The test results show that this product can significantly reduce the whole blood viscosity of chloasma mice, improve blood viscosity, and reduce the production of skin melanin.

[0013] 1.2 Purpose of the test

[0014] To observe the effect of the extracts of C. chinensis and Salvia miltiorrhiza on the viscosity of whole blood and the level of melanin production in mice with melasma after intragastric administration.

[0015] 1.3 Test material

[0016] 1.3.1 Test drugs

[0017] Catch yellow grass, Salvia miltiorrhiza ...

Embodiment 2

[0046] Embodiment 2 thick paste preparation

[0047] Salvia miltiorrhiza 300g, add 90% ethanol to reflux for 1.5 hours, filter, recover the ethanol from the filtrate to a thick paste; add 835g of salvia miltiorrhiza and sagegrass, add water to decoct twice, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate Form a clear paste with a relative density of 1.15-1.18 (60-65°C), cool it, add ethanol to make the alcohol content reach 60%, stir, let stand, filter, wash the precipitate three times with 60% ethanol, combine the washing liquid and the filtrate , recovering ethanol and concentrating it into a thick paste with a relative density of 1.30 to 1.32; combining the above two thick pastes for later use.

Embodiment 3

[0048] Example 3 tablet

[0049] Take the thick ointment of Example 2, add appropriate amount of starch, dextrin, microcrystalline cellulose, magnesium stearate, etc., mix evenly, granulate, dry, granulate, and tablet, to obtain. And it can be made into ordinary tablets, dispersible tablets and effervescent tablets according to the different types of excipients added.

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Abstract

The invention provides an application of a medicinal preparation for preparing a medicine used for treating a chloasma disease. The medicinal preparation is a thick paste prepared by 835 g of penthorum Chinense pursh and 300 g of the root of red-rooted salvia.

Description

technical field [0001] The invention relates to a medical application of a pharmaceutical preparation, which belongs to the field of food and medicine, and in particular relates to the application of the pharmaceutical preparation using C. chinensis and salvia miltiorrhiza as raw materials for preparing anti-chloasma medicine. Background technique [0002] Melasma (Chloasma, Melasma), also known as liver spots, is a kind of facial melanosis, which is a pigmentation spot that occurs on the face. Currently, traditional Chinese medicine is mainly used for symptomatic treatment. The occurrence of chloasma is related to the imbalance of the liver, spleen, and kidney. The traditional Chinese medicine classification includes liver depression and qi stagnation type, which should be treated to soothe the liver and relieve depression, and regulate qi and blood; For phlegm and blood stasis; for deficiency of kidney qi, it should be treated by tonifying the kidney and regulating menstru...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P17/00
Inventor 黄绍渊张浩张玲
Owner CHENGDU LIST PHARMA
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