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Pharmaceutical preparation containing axillary choerospondias fruit and preparation method and application thereof

A pharmaceutical preparation, the technology of jujube, which is applied in the field of medicinal preparations containing jujube and its preparation, can solve the problems of insufficient concentration rate, inconvenient refining, and the influence of active ingredients of the medicine, and achieves small toxic and side effects, easy preparation, and remarkable effect Effect

Inactive Publication Date: 2010-05-05
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are quite a few such medicines, but some tend to invigorate the heart yang, some favor nourishing the heart yin, some supplement both yin and yang, and are combined with blood-activating and stasis-removing medicines. There are relatively many such prescriptions, but these medicines are generally Lack of fast-acting drugs, so the effect on angina pectoris is not ideal
[0004] The following disadvantages exist in the preparation of traditional Chinese patent medicines: (1) It is difficult to extract the water-insoluble components in the medicine by traditional extraction methods; (2) During the extraction process, the organic solvent may interact with the active ingredients, causing the medicine to lose its original effect; (3) The non-effective ingredients in the medicine cannot be removed to the greatest extent, and the concentration rate is not high enough; (4) In addition to the active ingredients, the Chinese medicine extract also contains more impurities and fat-soluble ingredients, which brings inconvenience to the refining; (5) High temperature operation has a greater impact on the active ingredients in the drug

Method used

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  • Pharmaceutical preparation containing axillary choerospondias fruit and preparation method and application thereof
  • Pharmaceutical preparation containing axillary choerospondias fruit and preparation method and application thereof
  • Pharmaceutical preparation containing axillary choerospondias fruit and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 preparation of dripping pills containing jujube

[0045] Weigh 50g of jujube and add 8 times the amount of 70% ethanol to extract twice, each time for 1 hour, filter, combine the filtrate, recover the ethanol until it has no alcohol smell, concentrate to 0.3g / ml concentrate, AB-8 macroporous resin For purification, the purified solution was further concentrated to a relative density of 1.20 (20° C.), and the concentrated solution was used for later use.

[0046] Weigh 50g of Salvia miltiorrhiza, 30g of Sanqi and 30g of leeches, add 8 times the amount of 60% ethanol to extract twice, each time for 1 hour, filter, combine the filtrates, recover the ethanol until there is no alcohol smell, concentrate to a relative density of 1.20 (20°C ), combined with the above-mentioned jujube concentrate and continued to concentrate to a clear paste with a relative density of 1.30 (20°C).

[0047] Weigh 50 g of radix burdock and extract with supercritical fluid extraction...

Embodiment 2

[0049] Example 2 Preparation of granules from medicinal preparations containing Jujube

[0050] Weigh 50g of jujube, add 8 times the amount of 70% ethanol to extract twice, each time for 1 hour, filter, combine the filtrate, recover the ethanol until it has no alcohol smell, concentrate to 0.3g / ml concentrate, AB-8 macroporous For resin purification, the purified solution was further concentrated to a relative density of 1.25 (20° C.), and the concentrated solution was used for later use.

[0051] Weigh 50g of Salvia miltiorrhiza, 30g of Rhizoma Chuanxiong, 30g of safflower and 30g of Jujube seed, add 8 times the amount of 60% ethanol to extract twice, each time for 1 hour, filter, combine the filtrate, recover the ethanol until it has no alcohol smell, and concentrate to a relative density of 1.25 (20°C), combined with the above-mentioned jujube concentrate and continued to concentrate to a clear paste with a relative density of 1.35 (20°C).

[0052] Weigh 50 g of burdock and ...

Embodiment 3

[0054] Example 3 preparation of hard capsules containing Jujube

[0055] Weigh 50g of jujube, add 8 times the amount of 70% ethanol to extract twice, each time for 1 hour, filter, combine the filtrate, recover the ethanol until it has no alcohol smell, concentrate to 0.3g / ml concentrate, AB-8 macroporous For resin purification, the purified solution was further concentrated to a relative density of 1.22 (20° C.), and the concentrated solution was used for later use.

[0056] Take by weighing 50g of Salvia miltiorrhiza and 30g of triangular root, add 8 times the amount of 60% ethanol to extract twice, each time for 1 hour, filter, combine the filtrate, reclaim the ethanol until there is no alcohol smell, concentrate to a relative density of 1.24 (20 ° C), and the above Jujube concentrated liquid is combined and continues to be concentrated to a clear paste with a relative density of 1.33 (20°C).

[0057] Weigh 50 g of burdock and extract with supercritical fluid extraction.

...

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Abstract

The invention discloses a pharmaceutical preparation containing axillary choerospondias fruit and a preparation method and an application thereof. The pharmaceutical preparation containing the axillary choerospondias fruit comprises the following components by parts by weight: 50-300 parts of axillary choerospondias fruit, 30-200 parts of radix salviae miltiorrhizae and 20-300 parts of holy basil; and the pharmaceutical preparation further comprises 2-20 parts by weight of styrax and 20-200 parts by weight of rosewood heart wood. The invention further discloses the preparation method and the application of the pharmaceutical preparation containing the axillary choerospondias fruit. The pharmaceutical preparation containing the axillary choerospondias fruit is used for preparing drugs for treating cardiovascular diseases, takes the pain-relieving as the manifestation, takes the achievement of smooth blood vessels by promoting blood circulation for removing blood stasis as the root, thereby treating both manifestation and root cause of the diseases; and the prepration method of the pharmaceutical composition is combined with the modern extraction technology, thereby retaining the pharmaceutical active ingredients to the maximum extent and fully playing the pharmaceutical efficacy.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a medicinal preparation containing jujube and its preparation method and application. Background technique [0002] With the improvement of social living standards and the transition to an aging society, cardiovascular and cerebrovascular diseases have become a major killer of human health, and coronary atherosclerotic heart disease (commonly known as coronary heart disease) and angina pectoris are the most common cardiovascular and cerebrovascular diseases. Diseases have become the focus of drug research for cardiovascular and cerebrovascular diseases. Chinese medicine studies have found that traditional Chinese medicine plays an extremely important role in the prevention and treatment of cardiovascular and cerebrovascular diseases. [0003] At present, there are many Chinese patent medicines for the treatment of coronary heart disease in the market, such as Compound Danshen Tablets, Co...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K36/9066A61K36/902A61K36/725A61P9/10A61K31/045A61K35/62
Inventor 梁生旺赵玉梅周立艳陈春燕付立娇黎瑞汝
Owner GUANGDONG PHARMA UNIV
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