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Application of pectic acid oligosaccharide in preparing health-care product treating gastric ulcer

A technology of health care products and gastric ulcer, applied in the field of functional food, can solve the problems of high recurrence rate, adverse side effects and other problems, and achieve the effect of large application prospects, no toxic side effects, and good solubility

Inactive Publication Date: 2010-01-27
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These drugs have received good therapeutic effects, but after drug withdrawal, the recurrence rate of the disease is very high
At the same time, long-term drug maintenance treatment will bring other adverse side effects. Therefore, countries are still trying to find new anti-ulcer drugs with good curative effect and less toxic side effects.

Method used

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  • Application of pectic acid oligosaccharide in preparing health-care product treating gastric ulcer
  • Application of pectic acid oligosaccharide in preparing health-care product treating gastric ulcer
  • Application of pectic acid oligosaccharide in preparing health-care product treating gastric ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Preparation of pectin acid oligosaccharides:

[0017] (1) Obtaining pectin: extract the hawthorn fruit or the residue after juicing through an oxalic acid solution (pH2-6, 50-90°C) for 3 hours, and use the conventional pectin recovery method to precipitate with ethanol to recover the hawthorn pectin.

[0018] (2) Take an aqueous hawthorn pectin solution with a mass percent concentration of 1%, adjust the pH to 3, and decompose at 110° C. for 3 hours to obtain a hawthorn pectin decomposition product;

[0019] (3) The hawthorn pectin decomposition product is subjected to ultrafiltration and nanofiltration treatment with a hollow fiber membrane, and after recovering the oligosaccharide mixture with a molecular weight below 6000 Daltons, the oligosaccharide mixture with a molecular weight of 200 to 6000 is recovered with a nanofiltration membrane, and the bio -gel P-2 and Sephadex G-25 gel column chromatography to obtain hawthorn pectin acid oligosaccharides with an ov...

Embodiment 2

[0030] (1) Preparation of pectin acid oligosaccharides:

[0031] (1) Obtaining pectin: after the apple juice is processed, the juice residue is passed through water (50-100° C.), extracted for 3 hours, filtered, and the filtrate is precipitated with ethanol according to the conventional pectin recovery method, and the apple fruit is recovered. glue.

[0032] (2) Take an aqueous solution of apple pectin with a mass percent concentration of 2%, adjust the pH to 2, and decompose at 95° C. for 24 hours to obtain a decomposition product of apple pectin;

[0033] (3) Treat the apple pectin decomposition product with a ceramic membrane to recover the oligosaccharide mixture with a molecular weight below 6000 Daltons, then recover the oligosaccharide mixture with a molecular weight of 200 to 6000 with a nanofiltration membrane, and use Sephadex G-25 gel column layer The apple pectin acid oligosaccharides with a coincidence degree of 2-20 were obtained by analysis and separation.

[...

Embodiment 3

[0044] (1) Preparation of pectin acid oligosaccharides:

[0045] (1) Obtaining pectin: pass the citrus skin capsules through hydrochloric acid (pH 2-6, 50-90°C), extract for 3 hours, filter, and the filtrate is precipitated with ethanol according to the conventional pectin recovery method, and recovered to obtain citrus pectin .

[0046] (2) Take an aqueous solution of citrus pectin with a mass percentage concentration of 1%, adjust the pH to 4, and decompose at 120° C. for 15 minutes to obtain a citrus pectin decomposition product;

[0047] (3) The citrus pectin decomposition product is subjected to ultrafiltration and nanofiltration treatment with a hollow fiber membrane, and after recovering the oligosaccharide mixture with a molecular weight below 6000 Daltons, the oligosaccharide mixture with a molecular weight of 200 to 6000 is recovered with a nanofiltration membrane, and the bio -gel P-2 and Sephadex G-25 gel column chromatography to obtain citrus pectin acid oligosac...

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Abstract

The invention relates to an application of pectic acid oligosaccharide in preparing a health-care product treating gastric ulcer. The invention adopts the technical scheme that firstly, pectin is dissolved in water, and a pectin decomposer is prepared by a decomposition reaction; the pectin decomposer is processed by using a hollow fibre film or a ceramic filtration film, an oligosaccharide mixture with the molecular weight of 200-6000 daltons is processed and recovered by using a nano filtration film after an oligosaccharide mixture with the molecular weight being below 6000 daltons is recovered, and the pectic acid oligosaccharide with the superposition degree of 2-20 is obtained by the chromatographic separation of a Bio-gel P-2 gel column and / or a Sephadex G-25 gel column or the filtration of DEAE-Sephadex A-25 anion exchange resin. The prepared pectic acid oligosaccharide and auxiliary materials are matched to prepare health-care products with various forms and components for treating the gastric ulcer. The invention adopts a congeneric theory of medicines and foods, has no toxic or side effect and can be taken for a long time. By verification, the invention has obvious curative effect to sour burning type gastric ulcer.

Description

technical field [0001] The invention belongs to the field of functional foods, and in particular relates to the application of pectin acid oligosaccharides in the preparation of health care products for treating gastric ulcer. Background technique [0002] In modern society, due to people's partial eclipse, overeating, full food, unbalanced life and eating habits, lack of exercise, work pressure and other living habits, as well as changes in dietary structure, gastric ulcer has become an important lifestyle disease that endangers human physical and mental health. It has brought a huge burden to people's body, spirit, economic life and social medical care. The pathogenesis of ulcer is relatively complicated. It is generally believed that gastric ulcer is a chronic disease with multiple etiologies, and hypersecretion of gastric acid is one of the important reasons for the occurrence of ulcer. At present, the drugs for the treatment of peptic ulcer can be roughly divided into ...

Claims

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Application Information

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IPC IPC(8): A23L1/30A61K31/732A61P1/04A23L33/105A23L33/125
Inventor 李拖平李苏红王娜郭梅
Owner LIAONING UNIVERSITY
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