Method for extracting xanthohumol in hop residue by supercritical CO2 technology

Abstract

The invention discloses a method for extracting xanthohumol in hop residue by supercritical CO2 technology, and relates to hop technology. The method comprises the following steps: taking raffinate (the hop residue) after alpha acid is extracted from hop by supercritical CO2 as a main raw material, adopting the supercritical CO2 technology, taking ethanol or methanol as an entrainer, and obtaining coarse xanthohumol; performing concentration and spray drying to obtain a coarse product of xanthohumol; and purifying to obtain a high-purity xanthohumol product. The method utilizes the raffinate after alpha acid is extracted from hop by supercritical CO2, and belongs to resource recycling. The method has simple process; the obtained xanthohumol product has good characteristics of high activity and good dissolubility; and the technological process is environment-friendly.

Description

technical field [0001] The invention relates to the technical field of hops, and is a kind of 2 A method for extracting xanthohumol from hop dregs and the preparation of xanthohumol products. Background technique [0002] Xanthonumol is a unique functional substance of hops (Humulus lupulus L.). Xanthohumol is a flavonoid compound containing isoprenyl (structural formula such as figure 1 shown), hops are the only source of natural prenyl flavonoids found so far. The content of xanthohumol in hops is only 0.1% to 1.0%. [0003] Xanthohumol was first discovered in hops in 1913, and its molecular structure began to be studied in 1950. At that time, researchers did not pay attention to its health effects. It was not until 1990 that the effect of this substance was known. Know. Studies have found that xanthohumol in hops can prevent the enzymes that cause cancer cells to grow, and can help the body eliminate other carcinogens, especially in the early stages of cancer, and th...

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Problems solved by technology

Domestic patents such as CN101337876A, CN101440029A, and CN101433592A all use organic solvents to extract xanthohumol. In 2005, Dr. Xiong Haoping of Zhejiang University reported the paper "Research on Chemical Components of Hops and Purification Technology of Xanthohumol" using supercritical CO 2 The extraction research of xanthohumol in hops is carried out by using advanced technology, but this research only studies the supercritical extraction parameters, and does not mention the separation parameters, and the application of this research to the subsequent purification research of finished products is slightly insufficient, industrial application The prospect is poor, and the extraction efficiency is low; while foreign reports on xanthohumol extraction technology mainly focus on the use of supercritical CO 2 Both extraction (eg CA2451461) and organic solvent extraction (eg US3794744, US6867332, WO2009 / 023710)

In the above studies, the xanthohumol product obtained by extraction with organic solvents may have solvent residues and poor solubility, and the operating environment is poor, which is likely to cause human injury and other problems; while using supercritical CO 2 Reports on extraction technology may have problems such as high equipment requirements and high operating costs

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