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Medical compound micropore polysaccharide and application thereof

A polysaccharide and microporous technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of slow water absorption, difficult degradation, poor adhesion, etc., and achieve the effect of light tissue reaction and short hemostasis time

Active Publication Date: 2009-11-25
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has good biocompatibility and has a certain hemostatic effect, it absorbs water slowly and has poor adhesion. For large-scale bleeding, it still cannot achieve a good hemostatic effect.
Document "Preparation and Adsorption Properties of Chitosan / Starch Blended Microspheres" (Journal of Wuhan University, April 2006, Volume 52, No. 2, 189-192), mixing starch and chitosan in a certain proportion , using formaldehyde and epichlorohydrin as cross-linking agents, prepared chitosan / starch microspheres by reverse suspension method, used to adsorb metal ions such as copper and lead, because chitosan is the product of chitin deacetylation, It can only be dissolved in acid and acidic solution. The microspheres obtained after cross-linking have poor water absorption and are not easy to degrade, so they are not suitable for hemostasis on surgical wounds

Method used

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  • Medical compound micropore polysaccharide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation method of medical composite microporous polysaccharide

[0026] 1) Preparation of starch liquid

[0027] Accurately weigh 10.0 g of starch, measure 100 ml of distilled water with a measuring cylinder, add it to the starch, and heat it in a water bath until it becomes a paste.

[0028] 2) Dissolution of carboxymethyl chitosan

[0029] Weigh 1.0 g of carboxymethyl chitosan, add it to 500 ml of water with stirring, and dissolve it to clarify.

[0030] 3) Mix

[0031] ①Add the carboxymethyl chitosan solution to the starch solution and stir evenly. Adjust the pH to 9.0-10.0 with the prepared NaOH solution; ② Adjust the temperature of the water bath of the reactor to 60°C, add 500ml of liquid paraffin, stir, add 5.0g of Span 60 emulsifier, and after the solution reaches 60°C, add the above mixture, stirring vigorously.

[0032] 4) Emulsifying cross-linking copolymerization

[0033] Add 2ml of epichlorohydrin, react for 5h, stop stirring, and disch...

Embodiment 2

[0037] 1) Preparation of starch liquid

[0038] Accurately weigh 10.0 g of starch, measure 200 ml of distilled water with a measuring cylinder, add it to the starch, and heat it in a water bath until it becomes a paste.

[0039] 2) Dissolution of carboxymethyl chitosan

[0040] Weigh 0.1 g of carboxymethyl chitosan, add 10 ml of distilled water under stirring, dissolve and clarify.

[0041] 3) Mix

[0042] ①Add the carboxymethyl chitosan solution to the starch solution and stir evenly. Adjust its pH to 9.0 with the prepared NaOH solution and add 5ml of epichlorohydrin; ② adjust the temperature of the water bath of the reactor to 70°C, add 250ml of liquid paraffin, stir, add 10.0g of Span 80 emulsifier, and wait for the solution to reach 70 After ℃, the above mixture was added and stirred vigorously.

[0043] 4) Emulsifying cross-linking copolymerization

[0044] Add 15ml of formaldehyde, react for 10h, stop stirring, and discharge.

[0045] 5) Refined

[0046] After the...

Embodiment 3

[0047] Example 3: Preparation method of medical composite microporous polysaccharide

[0048] 1) Preparation of starch liquid

[0049] Accurately weigh 10.0 g of starch, measure 50 ml of distilled water with a measuring cylinder, add it to the starch, and heat it in a water bath until it becomes a paste.

[0050]2) Dissolution of carboxymethyl chitosan

[0051] Weigh 0.3 g of carboxymethyl chitosan, add 100 ml of distilled water under stirring, dissolve and clarify.

[0052] 3) Mix

[0053] ①Add the carboxymethyl chitosan solution to the starch solution and stir evenly. Adjust its pH to 7.0-8.0 with the prepared NaOH solution, and add 1.0 ml of formaldehyde; ② adjust the water bath temperature of the reactor to 65°C, add 1000ml of petroleum ether, stir, add 15g of Tween 60 emulsifier, and wait for the solution to reach 65 ℃, add the above mixture and stir vigorously.

[0054] 4) Emulsifying cross-linking copolymerization

[0055] The reaction was carried out for 3h, the ...

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Abstract

The invention relates to a medical compound micropore polysaccharide and application in hemostasis on wound surface bleeding areas of various wounds and operation tissues. The medical compound micropore polysaccharide is prepared by adopting a method with the following steps: (1) preparing starch fluid; (2) preparing carboxymethyl chitosan solution; (3) mixing the starch fluid and the carboxymethyl chitosan solution, and adding dispersant and emulsifier into the mixture; (4) emulsifying, crosslinking and co-polymerizing; and (5) refining, drying, packing and sterile treatment. The invention also discloses application of the medical compound micropore polysaccharide in preparing a hemostasis medicament used for the wound surface bleeding areas of wounds and operation tissues. The medical compound micropore polysaccharide of the invention has the following characteristics: 1, the hemostasis time is short, namely the hemostasis is generally finished in 3 to 5 minutes; 2, the medical compound micropore polysaccharide has no antigenicity, has polysaccharide components, and has no protein or immune reaction; 3, the medical compound micropore polysaccharide can be fully degraded and absorbed in vivo; 4, the medical compound micropore polysaccharide is a sterile product and is convenient to use by opening; and 5, the tissue reaction is light. Therefore, the medical compound micropore polysaccharide is a comparatively ideal surgical hemostasis product.

Description

technical field [0001] The invention relates to a medical composite microporous polysaccharide and its application in hemostasis of various wounds and bleeding areas of surgical tissue wounds. Background technique [0002] Wound hemorrhage is the most common surgical problem, which can lead to blood transfusion and related complications. Excessive intraoperative bleeding prolongs the operation time, and severe complications such as hemorrhagic shock and even death of patients occur. Physicians make work difficult, and they cause undue losses to patients. At present, many local hemostatic materials have been used in the clinic, which can be roughly divided into two categories: one type does not rely on the patient's own coagulation system to form a hemostatic clot (such as fibrin glue); Hemostasis (eg, gelatin sponge, etc.), which have different hemostatic effects, but are ineffective in heparinized patients, and some have the risk of allergies and virus transmission. There...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/60A61L15/64
Inventor 邹方明李延荣时丹左立姜丽娟
Owner SAIKE SAISI BIOTECH CO LTD
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