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Preparation method and use method of biologically degradable shape memory tubular support stent

A biodegradable, tubular support technology, applied in stents, medical science, prostheses, etc., can solve problems such as the need for external high temperature, the inability to precisely control the glass transition temperature of the final product in advance, and the pain of patients

Inactive Publication Date: 2009-10-14
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the recovery temperature of existing biodegradable shape memory polymer stents is usually higher than body temperature, so that external high temperature is required for shape recovery, which brings inconvenience to the operation and brings pain to the patient.
Moreover, the existing preparation methods cannot accurately control the glass transition temperature of the final product in advance.

Method used

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  • Preparation method and use method of biologically degradable shape memory tubular support stent
  • Preparation method and use method of biologically degradable shape memory tubular support stent
  • Preparation method and use method of biologically degradable shape memory tubular support stent

Examples

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Effect test

Embodiment 1

[0030] A specific embodiment of the present invention is a method for preparing a biodegradable shape memory tubular support stent, the steps of which are:

[0031] A. Preparation of biodegradable shape memory polymer material with a glass transition temperature of 5-37°C.

[0032] Physical blending method: at least one biodegradable shape memory polymer material with a glass transition temperature lower than 37°C is physically blended with at least one biodegradable shape memory polymer material with a glass transition temperature higher than 37°C; The mass ratio between the polymer materials used for blending is determined by the following formula (1):

[0033] 1 T g = w 1 T g 1 + w 2 T ...

Embodiment 2

[0040] This example is basically the same as Example 1, except that the biodegradable shape-memory polymer material with a glass transition temperature higher than 37°C is changed to poly-L-lactic acid with a molecular weight of 180,000, and its glass transition temperature (T g1 ) is 58°C. Calculate according to formula (1), the mass ratio W of poly-L-lactic acid and poly-ε-caprolactone 1 :W 2 It is 83:17.

Embodiment 3

[0042] This example is basically the same as Example 1, except that the glass transition temperature is lower than 37° C. The biodegradable shape memory polymer material is changed to polydioxanone, and its glass transition temperature (T g1 ) is 5°C. Calculate according to formula (1), the mass ratio W of poly DL-lactic acid and polydioxanone 1 :W 2 It is 52:48.

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Abstract

The invention discloses a preparation method and a use method of biologically degradable shape memory tubular support stent, wherein the steps of the preparation method comprises physical blending technology, in which the vitrification point of at least one component is below 37 DEG C and that of at least one component is beyond 37 DEG C, or chemical copolymerizing technology, in which two monomers are chemically polymerized to form degradable shape memory high polymer material composed of chain segment 1 and chain segment 2; the vitrification point of the chain segment 1 is below 37 DEG C; and the vitrification point of the chain segment 2 is beyond 37 DEG C; according to FOX formulation, the mass ratio of each polymer in physical blending technology is calculated, and the mass ratio of two monomers in chemical blending technology is also calculated, thereby ensuring that the prepared stent can recover to memorized shape at 37 DEG C of body temperature; therefore, the stent can recover to memorized shape naturally without external heating if the stent is implanted into human body; the stent is featured with convenient operation, high compliance of patients, easy preparation, no toxic matter introduced, high biocompatibility and safety.

Description

technical field [0001] The invention relates to a preparation method and application method of a biodegradable shape memory tubular support bracket. Background technique [0002] The esophagus, blood vessels, and urinary catheters are important tubular organs in the human body. If they become cancerous, they will cause local stenosis, cause the organs to lose their functions, and threaten human life. For this kind of stenosis problem, the world has already had a very mature solution, that is, to restore the smooth work of tubular organs through endovascular interventional therapy. For example, artificial interventional treatment is performed by applying shape memory scaffolds of biodegradable materials. Using materials with shape memory function, the stent can be placed into the body in a small and easy-to-place shape; then, it returns to a predetermined (memory) shape in the body to play its role in supporting and treating stenosis; at the same time, the material is also ...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61F2/82
Inventor 周绍兵俞雄军肖宇郭涛龚韬黄茂涛曹亚玲季代金
Owner SOUTHWEST JIAOTONG UNIV
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