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Fluidic cell manipulator

A manipulator and flow generator technology, applied in the field of particles, can solve the problems of false detection, hindered detection, etc., and achieve the effect of small change and/or damage

Inactive Publication Date: 2009-09-30
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the orientation of a cell can play a major role in the characterization of a cell, for example false detections can occur when a particle hinders the detection of particle features present on the back of the particle, or when a predetermined orientation of a particle is beneficial for manipulating that particle

Method used

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  • Fluidic cell manipulator
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Examples

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Embodiment Construction

[0038] The present invention is described below with reference to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. Any reference signs in the claims should not be construed as limiting the scope. The figures shown are only schematic and not restrictive. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes.

[0039] If the term "comprising" is used in the description and claims, it does not exclude other elements or steps. If one is used when referring to a singular noun, it includes a plural of that noun unless specifically stated otherwise. Furthermore, the terms first, second, etc. in the description and claims are used to distinguish similar elements and not necessarily to describe a temporal or spatial order in ranking or in any other way. Furthermore, the terms top, bottom, etc. in the specification and claims are used for descr...

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Abstract

The present invention discloses a system (100) for individually manipulating, e.g. orienting, a particle (104) in a fluid (106). The manipulating system (100) comprises a particle trapping system (111) allowing trapping of the particle (111) in a fluid channel (102) and a controller for controlling shear force gradients on the particle. Shear force gradients on the particle are 5 controlled by positioning a particle off center in the fluid channel (102) in a laminar flow or by controlling the laminar flow itself. The laminar flow thereby is generated using a flow generator (108). The system (100) for manipulating may be used in a particle characterization system or may be used for performing actions on the particle (104) under predetermined orientations.

Description

technical field [0001] The present invention relates to the field of particle characterization and manipulation. More specifically, the invention relates to methods and systems for manipulating objects or particles, such as biological cells, to examine or characterize them, and to software for implementing such methods. Background technique [0002] Analyte characterization is often used in chemical, biochemical or biological assays to detect the presence of certain types of analytes. For example, by detecting and / or characterizing cellular properties, malignant cells, such as precancerous cells, can in principle be detected, thereby offering the possibility to detect and / or monitor disease progression, such as progression from pre-invasive to invasive. Detection and / or characterization of individual particles, as commonly used in biosensor applications, allows qualitative and quantitative results to be obtained. One option for detecting the properties of individual partic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/14G01N33/483
CPCB03C1/282G01N2015/1415G01N15/1404B03C5/026
Inventor D·B·范达姆T·J·德胡格J·M·伦森S·I·E·武尔托
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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