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Styrax plant and use of extract thereof

A technology of benzoin and extract, which is applied in the pharmaceutical field of preparation of acyl-CoA:cholesterol acyltransferase inhibitors and traditional Chinese medicine extracts to achieve clear and controllable effects

Active Publication Date: 2009-08-12
CHENGDU DIAO JIUHONG PHARMA FAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no extract of 2-arylbenzofuran from plants of the genus Benzoin as an ACAT inhibitor for the prevention or treatment of atherosclerosis, hyperlipidemia, angina pectoris, myocardial infarction, cerebral infarction, Alzheimer's disease, Documentation or research reports on acute coronary syndrome, coronary artery restenosis after PTCA or stent placement, excessive sebum production, etc.

Method used

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  • Styrax plant and use of extract thereof
  • Styrax plant and use of extract thereof
  • Styrax plant and use of extract thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1 The preparation of the original medicine powder of Wasan benzoin

[0054] Take the dried fruit of benzoin wasan, grind it according to the conventional method, and sieve it to make fine powder of benzoin wasan with a particle size of 60-80 mesh, that is, the original medicinal powder of benzoin wasan.

Embodiment 2

[0055] Embodiment 2 Preparation of Washan Benzoin Extract

[0056] Wash 1000g of dried benzoin fruit, crush it, add 8L of 80% ethanol solution, extract by heating and reflux for 1.5 hours, add 6L of 80% ethanol solution to the filter residue, extract by heating and reflux for 1 hour, and filter. The two filtrates were combined and concentrated under reduced pressure to obtain 248 g of total extract. After dissolving the total extract with 2L hot water, extract 5 times with 3L industrial petroleum ether. Take 2 kg of D101 macroporous resin and pack it into a column. After the water layer is absorbed by the macroporous resin, it is eluted with 15 L of water. The eluent is discarded, and then the column is eluted with 95% ethanol. The eluent is concentrated under reduced pressure to obtain an extract , and then vacuum or freeze-dried to obtain 226 g of dry powder, which was analyzed by HPLC and determined to have a 2-arylbenzofuran content of about 90% of the total weight.

Embodiment 3

[0057] Example 3 Preparation of Luchun Benzoin Extract

[0058] Luchun benzoin dried fruit 1000g, crushed, add 8L of 80% ethanol solution, extract by heating and reflux for 1.5 hours, add 6L of 80% ethanol solution to the filter residue, extract by heating and reflux for 1 hour, and filter. The two filtrates were combined and concentrated under reduced pressure to obtain 250 g of total extract. After dissolving the total extract with 2L hot water, extract 5 times with 3L industrial petroleum ether. Take 2 kg of D101 macroporous resin and pack it into a column. After the water layer is absorbed by the macroporous resin, it is eluted with 15 L of water. The eluent is discarded, and then the column is eluted with 95% ethanol. The eluent is concentrated under reduced pressure to obtain an extract , and then vacuum or freeze-dried to obtain 150 g of dry powder, which was analyzed by HPLC and determined to have a 2-arylbenzofuran content of 82% of the total weight.

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Abstract

The invention relates to a pharmaceutical use of styrax. The invention particularly relates to use of the styrax in the preparation of acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, and the styrax can be prepared into injections, oral tablets, capsules and a variety of preparations for being applicable to preventing and treating atherosclerosis, hyperlipidemia and other diseases. Furthermore, the styrax can be used as a preventive drug or a therapeutic agent for angina, myocardial infarction, cerebral infarction, Alzheimer's disease, acute coronary syndrome, PTCA or posterior coronary artery re-stenosis with stent and other diseases. The styrax can also be used as the therapeutic agent for regulating the functions of sebaceous glands and inhibiting excessive production of sebum, thereby being used for treating oily skin, acne, seborrhea, acne-like injuries caused by corticosteroids and other diseases.

Description

technical field [0001] The invention relates to a new pharmaceutical application of a traditional Chinese medicine extract, in particular to the application of a benzoin plant and its extract in the preparation of acyl-CoA:cholesterol acyltransferase inhibitor drugs, which belongs to the field of traditional Chinese medicine. Background technique [0002] Benzoinaceae (Styracaceae), also known as Jasminaceae and Oleanaceae, has about 11 genera and 180 species. There are 9 genera, 50 species and 9 varieties in China, with a wide distribution. Benzoin (Styrax Linn), also known as Jasminum genus, has about 130 species. There are about 30 species and 7 varieties in my country. It is mainly produced in the provinces and regions south of the Yangtze River Basin. Most of the benzoin family plants can be used for ornamental purposes, and some species are used for materials or medicinal purposes. Their resin contains more balsamic acid, which is called "benzoin". A valuable medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P3/06A61P9/10A61K131/00
Inventor 晏菊芳李麒麟颜永红王晓琴陈欣
Owner CHENGDU DIAO JIUHONG PHARMA FAB
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