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Method for preparing component in spikemoss for reducing blood sugar and regulating blood fat and novel use thereof

A technology of Selaginella and macroporous resin columns, which is applied in the field of medicine and can solve the problem of not being able to determine what the active ingredient is

Inactive Publication Date: 2009-07-22
赵全成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kang Wenyi and others reported that the acidic part in Selaginella was prepared by alkali extraction and acid precipitation method, and the content of biflavonoids in Selaginella spicosa was only 10-12%, and about 90% of other components were not clear. The experiment reported that the acidic extraction The extract has the effect of α-glucosidase inhibitor and hypolipidemic effect (Fine Chemical Industry, December 2008, Volume 25, Issue 12), the extract is still a very complex mixture, and its active ingredients cannot be determined what is

Method used

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  • Method for preparing component in spikemoss for reducing blood sugar and regulating blood fat and novel use thereof
  • Method for preparing component in spikemoss for reducing blood sugar and regulating blood fat and novel use thereof
  • Method for preparing component in spikemoss for reducing blood sugar and regulating blood fat and novel use thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] Example 1 , Extraction and preparation of the total flavonoids of Selaginella chinensis and the biflavonoids of Selaginella spica:

[0052] Medicinal material 1kg, reflux extraction with 30-95% ethanol (preferably 70% ethanol) 8 times for 2-3 times, each extraction for 1-3 hours, the extract is directly passed through the pre-treated D101 or AB-8 macroporous resin column , the resin column was eluted with 2 times column volume of 70% ethanol, the 70% ethanol solution was combined, and the ethanol concentration was adjusted to 30-60% (preferably 50-55%), and then directly passed through the polyamide column. The polyamide column is eluted with 2 times the column volume of 30-60% ethanol, and then 60-95% (preferably 80%) ethanol is used to elute the polyamide column, the 60-95% ethanol eluate is collected, the solvent is recovered, and dried to obtain a volume Total flavonoids of cypress. The total flavonoid content of Selaginella is 89.6%. The total flavonoids of Sela...

Embodiment 3

[0053] Example 3 , (capsules)

[0054] 100g of abiflavonoids or total flavonoids raw materials, appropriate amount of medicinal starch, mixed evenly, granulated, dried, granulated, filled into No. 1 capsules, made into 1000 capsules, and ready. 1 capsule each time, 3 times a day.

Embodiment 4

[0055] Embodiment 4 (tablet)

[0056] 100g of the raw material of amiflavonoids or total flavonoids, appropriate amount of medicinal starch, appropriate amount of dextrin, mix evenly, granulate, dry, granulate, dry, add appropriate amount of lubricant, compress into tablets, and make 1000 tablets, ready to serve. 1 tablet each time. 3 times a day.

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Abstract

The invention relates to high-content S.tamariscina(beav.)spring total flavonoids and a high-purity amentotaxus argotaenia biflavone monomer composition firstly prepared from Selaginella S.pvlvinata(Hook.et Gev.)Maxim, S.tamariscina(beav.) spring and S.moellendorfii Hieron by a macroporous resin and polyamide serial columns in series chromatography method. The S.tamariscina(beav.)spring total flavonoids and the amentotaxus argotaenia biflavone monomer composition are firstly proved to have functions of inhibiting alpha-glucosaccharase, reducing blood sugar, and regulating blood fat, and the S.tamariscina(beav.)spring total flavonoids and amentotaxus argotaenia biflavone in preventing have new application in treating hyperglycemia and hyperlipemia.

Description

technical field [0001] The invention relates to a new application of Selaginella, that is, total flavonoids of Selaginella and biflavone monomer components of Selaginella can be obtained through solvent extraction, separation and purification of Selaginella macroporous resin and polyamide series column chromatography. To be exact, it is the application of the total flavonoids of Selaginella extracted from Selaginella selaginella and the biflavonoids monomer components of Spicy chinensis in the preparation of hypoglycemic (α-glucosidase inhibitor) and blood lipid regulation. Pharmaceutical formulations of the drug are also involved. It belongs to the field of medical technology. Background technique [0002] Dried whole of Selaginella Selaginella (Selaginella) Selaginella Selaginella (Hook. et Gev.) Maxim, S. tamariscina (beav.) spring and Selaginella Hieron Grass. Selaginella plants have anti-cancer, anti-inflammation, anti-virus, analgesic, hypotensive, hypoglycemic, ant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P3/06A61P3/10
Inventor 赵全成张莲珠王莲萍南敏伦吕雪峰赫玉芳
Owner 赵全成
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