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Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use

A technology of glycoside derivatives, hyaluronic acid, applied in the field of skin care and/or its accessories, which can solve problems such as enhancing skin barrier function

Inactive Publication Date: 2009-07-15
LOREAL SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0038] However, these derivatives have hitherto never been used to improve and / or enhance skin barrier function, let alone in combination with hyaluronic acid

Method used

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  • Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
  • Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use
  • Composition comprising at least one c-glycoside derivative and at least one hyaluronic acid and its cosmetic use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0481] Example 1: Tests performed: Analysis of keratinocyte transglutaminase (TGk) activity

[0482] Study of the in vitro effect of two active agents on keratinocyte differentiation (C-β-D-xylopyranoside-2-hydroxypropane with 30% by weight of active substance in a 60 / 40 water / 1,2-propanediol mixture , and hyaluronic acid). For this purpose, normal human epidermal keratinocytes pretreated with mitomycin to prevent their proliferation in starved medium consisting of 40% depleted SFM medium and 60% Earl BufferSalt Sodium (EBSS) buffer (NHEK) in culture medium. The thus slowed metabolism of these cells - their ability to differentiate - is then quantified by analyzing the keratinocyte transglutaminase (TGk) activity of NHEK pretreated with active agents using standard radiochemical assays.

[0483] Calcium Chloride (CaCl 2 ) - a molecule known to stimulate keratinocyte differentiation was used as a reference molecule for this analysis.

[0484] operating procedures

[0485] ...

Embodiment 2

[0504] Example 2: Examples of Formulations

[0505] The content is expressed as mass percentage content.

[0506] Compositions A and B are H / E emulsions gelled with carbomer and / or ammonium polyacryloyldimethyltaurate and prepared according to conventional techniques. Composition B is very highly organosiliconated. Composition C is a highly organosiliconated E / H emulsion prepared according to conventional techniques. Composition D is a clear gel with a high concentration of hyaluronic acid gelled with ammonium polyacryloyldimethyltaurate.

[0507] A B C D magnesium sulfate 0.70 sodium hydroxide 0.08 Triethanolamine 1.23 0.01 0.02 Hydroxyethylpiperazineethanesulfonic acid 1.00 1.00 C-β-D-xylopyranoside-2-hydroxypropane (1) 1.00 1.00 1.00 1.00 algae extract 1.00 0.20 0.20 0.20 Distearyldimethylamine hectorite 0.20 silica 2.00 3.00 Acrylate Copolymer 0.30 Tris...

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Abstract

The present invention relates to a topical cosmetic and / or dermatological composition comprising, in a physiologically acceptable medium, at least one hyaluronic acid or a derivative thereof and at least one C-glycoside derivative.

Description

technical field [0001] The invention relates to the field of care of the skin and / or its annexes. [0002] A subject of the present invention is a topical dermatological and / or cosmetic composition comprising at least one hyaluronic acid or derivative thereof and at least one C-glycoside derivative in a physiologically acceptable medium. [0003] The invention also relates to a cosmetic therapy of the skin and / or its appendages for improving the barrier function, comprising at least one step of applying to the skin at least one composition as defined above. [0004] In particular, the compositions of the present invention are used to improve the barrier function of the skin. It is thus useful for hydration of the skin, improving skin suppleness, improving and / or reducing skin micro-relief, and combating signs of skin aging. Background technique [0005] Human skin is composed of two compartments, a deep part (dermis) and a superficial part (epidermis). [0006] The dermis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/60A61Q19/00A61Q19/08
Inventor L·比塞J·拉布罗J·塞内S·索赛
Owner LOREAL SA
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