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Medicament composition for ischemic disease and application thereof in medicinal preparation

A technology for pharmaceutical preparations and compositions, applied in the field of pharmaceutical preparations, can solve the problems of lack of specificity in clinical manifestations of ischemic bowel disease, shortage of raw material resources, and high cost of medicines, so as to reduce the viscosity of whole blood and reduce myocardial infarction. Scope, delaying the effect of thrombosis

Active Publication Date: 2009-06-24
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem with these drugs is that nitrates can develop resistance and drug dependence
The disadvantage is that the raw material resources of many medicines are in short supply, and the cost of medicines is high
In fact, the clinical manifestations of ischemic bowel disease often lack specificity
Therefore, it is often difficult to diagnose at an early stage
Furthermore, most of the existing thrombolytic and anticoagulant drugs for ischemic bowel disease are chemically synthesized drugs, which also have many adverse reactions

Method used

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  • Medicament composition for ischemic disease and application thereof in medicinal preparation
  • Medicament composition for ischemic disease and application thereof in medicinal preparation
  • Medicament composition for ischemic disease and application thereof in medicinal preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0196] The capsule preparation of medicine of the present invention:

[0197] Weigh 5kg of astragalus, 2kg of salvia miltiorrhiza, 1kg of chuanxiong, 1kg of safflower, and 1kg of earthworm.

[0198] Add astragalus, salvia miltiorrhiza, chuanxiong, safflower, and earthworm to 8 times the amount of 50% ethanol, soak and extract 3 times, each time for 3 hours, recover ethanol, concentrate to a relative density of 1.25 (75°C), add 55% ethanol, and carry out Alcohol precipitation, recovery of ethanol, concentrated into a clear paste.

[0199] The above clear paste is dried, pulverized and packed into capsules. Each capsule contains 10g of crude drug.

Embodiment 2

[0201] The injection of medicine of the present invention

[0202] Weigh 10kg of astragalus, 5kg of salvia miltiorrhiza, 3kg of chuanxiong, 3kg of safflower, and 1kg of earthworm.

[0203] The extract was prepared according to the method described in Example 1. The extract is subjected to depyrogenation treatment according to a conventional method and distilled water is added, the isotonic pressure is adjusted with sodium chloride, filtered, and filled. Prepare an injection containing 20g of crude drug per 10ml.

Embodiment 3

[0205] The tablet preparation of medicine of the present invention:

[0206] Weigh 15kg of astragalus, 8kg of salvia miltiorrhiza, 5kg of chuanxiong, 5kg of safflower, and 3kg of earthworm.

[0207] Soak Salvia Miltiorrhiza and Rhizoma Chuanxiong with 3 times the amount of 70% ethanol for 3 times, each time for 48 hours, combine the ethanol extracts, filter, recover the ethanol until it has no alcohol smell, and set aside. Add 8 times the amount of water to the dregs, astragalus, earthworm coarse grains, and safflower medicinal materials, decoct 3 times, 1 hour each time, combine the decoction, filter, concentrate the filtrate, combine with the alcohol extraction part, and continue to concentrate to relative density It is a clear paste of 1.30 (80°C). The prepared clear paste is added with auxiliary materials, mixed evenly, granulated, and pressed into tablets. Each tablet contains 5g of crude drug.

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PUM

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Abstract

The invention discloses a medicine composition for ischemic diseases, which comprises the following raw materials by weight portion: 5 to 15 portions of radix astragali, 2 to 8 portions of Salvia miltiorrhiza, 1 to 5 portions of ligusticum wallichii, 1 to 5 portions of safflower and 1 to 3 portions of earthworms. The invention simultaneously discloses application of the medicine composition in preparing pharmaceutical preparation for treating ischemic cerebrovascular disorder, application of the medicine composition in pharmaceutical preparation for treating ischemic cardiomyopathy, and application of the medicine composition in pharmaceutical preparation for treating ischemic enteropathy. The medicine composition can be used for preventing and treating ischemic diseases such as ischemic cerebrovascular disorder, ischemic cardiomyopathy and ischemic enteropathy, and can also be used for treating coronary heart disease, arteriosclerosis and mesenteric vein embolism. The medicine composition has strong pertinence and obvious medicine effect, and provides more application selections for clinical medication.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and its application, in particular to a pharmaceutical composition for ischemic diseases and its application in pharmaceutical preparations. Background technique [0002] Ischemic disease refers to the state of low blood flow in affected organs due to arterial spasm, stenosis, and chronic occlusion, resulting in organ atrophy, dysfunction, and even necrosis. Typical ischemic diseases include ischemic stroke, ischemic cardiomyopathy, and ischemic enteropathy. [0003] Ischemic stroke refers to the sudden decrease in blood perfusion or complete interruption of blood flow in the local blood supply arteries of the brain tissue, stopping blood supply, oxygen supply, sugar supply, etc., resulting in brain tissue ischemia and hypoxia, and a series of acute clinical symptoms . If the blood supply is not restored in time, nerve cells, glial cells and blood vessels will be necrotic, resulting in cerebral in...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/10
Inventor 李振江陈钟卢树杰姜海
Owner SHINEWAY PHARMA GRP LTD
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