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Chinese drug composition for senile dementia prevention and cure

A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, medical formula, plant raw material, etc., can solve the problems of limited therapeutic effect, indeterminate will, lack of guiding significance for clinical application of TCM syndrome differentiation, etc., achieving significant curative effect and improving living ability. , the effect of improving memory and cognitive ability

Inactive Publication Date: 2009-06-03
SICHUAN INDAL INST OF ANTIBIOTICS CHINA NAT PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the therapeutic effect of a single compound or a single target of traditional Chinese medicine is very limited, and there is a lack of guiding significance for the clinical application of TCM syndrome differentiation
Prediction pills are recorded in the "Taiping Huimin Hejiju Prescription" in the Song Dynasty. It is used to treat heart-qi deficiency, unsteady will, trance, language errors and other diseases. It has not been used for the treatment of AD or VaD.

Method used

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  • Chinese drug composition for senile dementia prevention and cure
  • Chinese drug composition for senile dementia prevention and cure
  • Chinese drug composition for senile dementia prevention and cure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Take 600g of Shichangpu, 1200g of Fushen, 600g of Zhizhizi, 600g of ginseng, and 600g of polygala. The above medicinal materials were purchased from the Hehuachi medicinal herb market in Chengdu.

[0051] Add 6 times the amount of water to the medicinal material of Shichangpu, extract it with a volatile oil extractor, separate the upper transparent oil layer, and obtain Shichangpu volatile oil, which is ready for use.

[0052] Fushen, Fuzhizi, ginseng, Polygala, add 8 times the amount of 95% ethanol, extract 4 times, each time for 1 hour, filter the alcohol extract while it is hot, combine, recover the ethanol until the extract has no alcohol smell, and concentrate to extract Paste, ready to use.

[0053] Add 10 times the amount of water to the residue of medicinal materials extracted by ethanol, extract once for 5 hours each time, combine the water extracts, concentrate to a relative density of 1.10-1.12, add 95% ethanol to make the concentration of ethanol reach 70%....

Embodiment 2

[0056] Take 600g of Shichangpu, 1200g of Fushen, 600g of Zhizhizi, 1200g of ginseng, and 600g of polygala. The above medicinal materials were purchased from the Hehuachi medicinal herb market in Chengdu.

[0057] Take the medicinal materials of Prezhizi, Ginseng, and Polygala, mix them evenly, beat them into coarse powder, add 10 times the amount of 70% ethanol, extract twice, each time for 3 hours, filter the alcohol extract while it is hot, combine it, and recover the ethanol until the extract is alcohol-free taste, the concentrated solution was loaded onto the treated AB-8 macroporous adsorption resin column 5 times the mass of the medicinal material, the loading speed was 1mL / min, and the operating temperature was controlled at room temperature. Pre-wash the resin column with deionized water and 20% ethanol solution of the volume of the resin column. After washing with the 20% ethanol solution, elute with 70% ethanol solution of 6 times the volume of the resin column at a ...

Embodiment 3

[0064] Take 1500g ginseng, 1500g yam, 1500g sealwort, 1500g white poria cocos, 1500g Fushen, 1500g medlar, 1500g zizhizi, 1500g shichangpu, 1500g digupi, 1500g baiziren, and 1500g polygala. The above medicinal materials were purchased from the Hehuachi medicinal herb market in Chengdu.

[0065] Add 10 times the amount of water to the medicinal material of Shichangpu, extract it with a volatile oil extractor, separate the upper transparent oil layer, and obtain Shichangpu volatile oil, which is ready for use.

[0066] Mix ginseng, yam, sealwort, Fushen, white tuckahoe, medlar, zizhizi, Shichangpu, Digupi, Baiziren, Polygala, add 10 times the amount of water to decoct, extract twice, 3 hours each time, The alcohol extracts were filtered while hot, combined, and the ethanol was recovered until the extracts had no alcohol smell, concentrated into extracts, and set aside.

[0067] Take the medicinal material residue after ethanol extraction, add 10 times the amount of water, extra...

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Abstract

The invention relates to a Chinese drug composition for senile dementia prevention and cure, consisting of the materials of the following weight: 100-500 ginseng, 100-1500 high aspiration, 100-1500 grass-leaved sweetflag, 100-1500 fushen and 100-1500 Akebia Fruit.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating senile dementia and a preparation method thereof, in particular to a traditional Chinese medicine composition for preventing and treating senile dementia or brain neurodegenerative diseases. Background technique: [0002] Alzheimer's disease includes Alzheimer's disease (Alzheimer's disease, AD) and vascular dementia (vasculardementia, VaD) and other types. A persistent high-level neurological activity disorder, that is, obstacles in memory, thinking, analysis and judgment, visuospatial recognition, emotion, etc. in the state of no disturbance of consciousness. Clinically, the treatment of Alzheimer's disease mainly uses acetylcholinesterase (AchE) inhibitors, anti-immune inflammation, antioxidants and other symptomatic drugs to temporarily alleviate the cognitive decline of patients, but there is no specific treatment or reversal of disease progression. d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61K36/8969A61P25/28
Inventor 何正有刘君焱曹华政杨放姚洁
Owner SICHUAN INDAL INST OF ANTIBIOTICS CHINA NAT PHARMA GROUP CORP
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