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Chemical composite preparation and use thereof

A compound and preparation technology, which is applied in the field of addiction medicine, can solve the problems of high cost, single effect, large toxic and side effects, etc., and achieve the effect of reducing the degree of drug craving

Inactive Publication Date: 2009-05-06
袁才蔚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0021] There are many kinds of therapeutic drugs in drug rehabilitation treatment, but the problems of high cost, large toxic and side effects, and single effect are more prominent

Method used

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  • Chemical composite preparation and use thereof
  • Chemical composite preparation and use thereof
  • Chemical composite preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] The raw materials used in the preparation are: GABA B Receptor agonist bulk drug baclofen, M receptor antagonist bulk drug atropine (Atropine), excipients (any one in starch, pregelatinized starch, dextrin); the active ingredient weight ratio of raw materials is: GABA B Receptor agonist raw material baclofen is 1-40%, M-receptor antagonist raw material atropine (Atropine) is 1-15%, and excipients are 45-98%. Tablets are made with conventional tablet-making equipment and technology .

Embodiment 2

[0072] The raw materials used in the preparation are: GABA B Receptor agonist raw material baclofen, M receptor antagonist raw material scopolamine (Scopolamine), excipients (any one in starch, pregelatinized starch, dextrin), the active ingredient weight ratio of raw materials is: GABA B Receptor agonist raw material baclofen is 1-40%, M-receptor antagonist raw material scopolamine (Scopolamine) is 1-15%, and excipients are 45-98%. Tablets are made with conventional tablet-making equipment and technology. agent.

Embodiment 3

[0074] The raw materials used in the preparation are: GABA B Receptor agonist bulk drug baclofen, M receptor antagonist bulk drug Pirenzepine (Pirenzepine), auxiliary material (any one in starch, pregelatinized starch, dextrin), the active ingredient weight ratio of raw material is: GABA B Receptor agonist raw material drug baclofen is 1-40%, M-receptor antagonist raw material drug Pirenzepine (Pirenzepine) is 1-15%, and excipients are 45-98%, made with conventional tablet-making equipment and technology tablet.

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Abstract

The invention relates to a chemical composite preparation and an application thereof, which belong to the technical field of addition medical applications and are characterized in that the chemical composite preparation consists of a GABAB receptor agonist material, an M receptor antagonist material and an auxiliary material (any one of starch, pre-gelatinized starch and dextrin), and the weight proportions of the effective constituents of the materials are as follows: 1 to 40 percent of the GABAB receptor agonist material, 1 to 15 percent of the M receptor antagonist material and 45 to 98 percent of the auxiliary material, and the materials are prepared into tablets according to the conventional method. The chemical composite preparation can be other preparations prepared by the conventional method after changing the auxiliary material. The chemical composite preparation is used for curing opioid type drug dependent patients in the aspects of drug discarding, rehabilitation and drug retaking resistance, and the healing effect is better than that of singly used M receptor antagonist or GABAB receptor agonist, and the invention has significant drug retaking resistant effect.

Description

Technical field: [0001] The present invention relates to a combination of muscarinic acetylcholine receptor (abbreviated M receptor) antagonist and gamma-aminobutyric acid B receptor (abbreviated GABA B Receptor) agonists and auxiliary materials prepared chemical drug compound preparations and applications thereof, which belong to the technical field of addiction medicine application. Background technique: [0002] At a time when the medical biological interventions of the opioid receptor system are being criticized and struggling, the research on the compensatory adaptation of the non-opioid receptor system and anti-opioid mental dependence and relapse drugs has attracted much attention. Over the past ten years, it has been found that some chemical substances have no direct effect on opioid receptors, but they can inhibit the occurrence of opioid tolerance and dependence. This prompts people to begin to explore the role of other receptor action systems in opioid dependence...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/38A61K31/4453A61K31/46A61K31/5513A61K31/66A61K9/20A61K47/36A61K47/40A61P25/36A61K31/195A61K31/165
Inventor 袁才蔚
Owner 袁才蔚
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