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Jasmine flower extract and preparation method and use thereof

A jasmine flower extract, jasmine flower technology, applied in the direction of medical formula, drug combination, plant raw materials, etc., to achieve the effect of reducing the content of aromatic components and high purity

Active Publication Date: 2009-04-29
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But so far there is no report of a jasmine extract whose main component is total flavonoids and can be used for the treatment of cardiovascular diseases

Method used

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  • Jasmine flower extract and preparation method and use thereof
  • Jasmine flower extract and preparation method and use thereof
  • Jasmine flower extract and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 jasmine flower extract

[0027] (1) reflux extracting jasmine with 95% ethanol solution, cooling the extract overnight, filtering, concentrating under reduced pressure to obtain the total extract; jasmine dregs for subsequent use;

[0028] (2), the total extract is fully suspended with 20% ethanol solution, the suspension is fully extracted with sherwood oil and ethyl acetate successively, the sherwood oil layer is discarded, and the ethanol solution layer after extraction is retained; the ethyl acetate layer, Concentrate under reduced pressure to constant weight to obtain ethyl acetate part extract;

[0029] (3), the jasmine flower dregs in the step (1) are reflux extracted with 60% ethanol solution, the extract is combined with the ethanol solution layer in the step (2), and concentrated under reduced pressure to form a secondary extract;

[0030] (4), the secondary extract is fully dissolved with an appropriate amount of distilled wat...

Embodiment 2

[0033] The preparation of embodiment 2 jasmine flower extract

[0034] (1) reflux extracting jasmine with 90% ethanol solution, cooling the extract overnight, filtering, and concentrating under reduced pressure to obtain the total extract; jasmine dregs for subsequent use;

[0035] (2), the total extract is fully suspended with 15% ethanol solution, the suspension is fully extracted with sherwood oil and ethyl acetate successively, the sherwood oil layer is discarded, and the ethanol solution layer after extraction is retained; the ethyl acetate layer, Concentrate under reduced pressure to constant weight to obtain ethyl acetate part extract;

[0036] (3), the jasmine flower dregs in step (1) are extracted with reflux of 50% ethanol solution, the extract is combined with the ethanol solution layer in step (2), and concentrated under reduced pressure to form a secondary extract;

[0037] (4), the secondary extract is dissolved with distilled water, filtered, and put on a polya...

Embodiment 3

[0040] The preparation of embodiment 3 jasmine flower extract

[0041] (1) extract jasmine flower with 100% dehydrated ethanol backflow, the extract is cooled overnight, filtered, and concentrated under reduced pressure to obtain the total extract; jasmine flower dregs are set aside;

[0042](2), the total extract is fully suspended with 30% ethanol solution, the suspension is fully extracted with petroleum ether and ethyl acetate successively, the petroleum ether layer is discarded, and the ethanol solution layer after extraction is retained; the ethyl acetate layer, Concentrate under reduced pressure to constant weight to obtain ethyl acetate part extract;

[0043] (3), the jasmine medicinal residues in the step (1) are reflux extracted with 70% ethanol solution, the extract is combined with the ethanol solution layer in the step (2), and concentrated under reduced pressure to form a secondary extract;

[0044] (4), the secondary extract is dissolved with distilled water, f...

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Abstract

The invention discloses a jasmine flower extract, a preparation method and an application thereof. The jasmine flower extract contains the following components: 70 percent to 75 percent of jasmine total flavonoids, 15 percent to 20 percent of jasmine non-flavonoid glycosides and 10 percent to 15 percent of jasmine volatile components. A main extraction solvents adopted by the invention when extracting jasmine flower is a mixed solution of ethanol and water in different proportions, and glycoside and aglucon in the flower can also be extracted; polyamide resin column is used for enriching total flavonoids so that impurities are removed and purity is increased; additionally, the method removes a plurality of jasmine fragrant ingredients, and the main effective components of the extract obtained is total flavonoids, the purity is high and the content of jasmine fragrant ingredients is greatly decreased. Pharmacology examination proves that, the extract has the functions of relaxing isolated vascular tissue, removing isolated oxygen free radical, reducing animal blood pressure, relieving myocardial ischemia, improving arrhythmia symptoms and anoxia test and can be applied to treating cardiovascular diseases.

Description

technical field [0001] The invention relates to a plant extract, in particular to a jasmine flower extract and a preparation method thereof. The invention also relates to the medical use of the jasmine flower extract in treating cardiovascular diseases, which belongs to the field of traditional Chinese medicine. Background technique [0002] The incidence of cardiovascular disease is increasing year by year in all countries in the world, and it has become the "number one killer" that threatens human health beyond cancer, and is the main cause of death of patients. According to WHO's statistics on the death of various diseases in the world, the number of deaths due to cardiovascular and cerebrovascular diseases accounts for 28.8% of the total number of deaths. It is estimated that by 2008, this proportion will rise to 36%, which will cause huge spiritual and economic burdens to the people and society. At present, the clinical treatment of ischemic heart disease such as hyper...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P9/06A61P9/10A61P9/12A61K133/00
Inventor 杨宝峰侯云龙乔国芬李国玉
Owner JIANGSU KANION PHARMA CO LTD
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