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Magnetic sensor device with reference unit

A magnetic sensor and sensor technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem that the effective gain is very sensitive, and achieve the effect of improving accuracy

Inactive Publication Date: 2009-03-04
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The problem with magnetic biosensors of the type described above is that the sensitivity of the magneto-resistive element is very sensitive to uncontrollable parameters such as magnetic instabilities in the sensor, external magnetic fields, aging, temperature, etc., and thus leads to an effective gain of the overall measurement for this also very sensitive

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Embodiment Construction

[0045] Like reference numerals in the drawings indicate the same or similar parts.

[0046] figure 1 A microelectronic magnetic sensor device according to the invention is shown, wherein it is used in particular as a biosensor for detecting magnetically interacting particles, such as superparamagnetic beads 2 , within a sample chamber 1 . Magnetoresistive biochips or biosensors have promising properties for biomolecular diagnostics in terms of sensitivity, specificity, integration, ease of use, and cost. Examples of such biochips are described in WO 2003 / 054566, WO 2003 / 054523, WO 2005 / 010542A2, WO 2005 / 010543A1 and WO 2005 / 038911A1, which are hereby incorporated by reference. However, the sensor device may also be any suitable sensor based on the detection of the magnetism of the particles to be measured located on or near the sensor surface. Therefore, the magnetic sensor device can be designed as a coil, a magnetoresistive sensor, a magneto-restrictive sensor, a Hall sens...

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Abstract

The invention relates to a magnetic sensor device comprising excitation wires (11, 13) for generating a magnetic field (B) in a sample chamber (1) and a magnetic sensor element (12), for example a GMR element, for sensing magnetic fields generated by magnetic particles (2) in the sample chamber. The device further comprises a reference field generator consisting of a linear conductor (14) and a planar conductor (15) between which the magnetic sensor element (12) is disposed. The magnetic reference field (Bref) generated by said conductors (14, 15) does not penetrate into the sample chamber (1) but reaches only the magnetic sensor element (12). Components of the sensor signal which are due to the magnetic reference field (Bref) can therefore be separated and used to calculate the sensor gain. This value can for example be used for an auto-calibration of the device during a measurement.

Description

technical field [0001] The invention relates to a magnetic sensor device comprising at least one magnetic sensor element and a sample chamber for providing a sample. Furthermore, the invention relates to the use of such a magnetic sensor device and a method for measuring a magnetic field with such a magnetic sensor device. Background technique [0002] WO 2005 / 010543 A1 and WO 2005 / 010542 A2 disclose a magnetic sensor device which can be used, for example, in a microfluidic biosensor to detect (biological) molecules labeled with magnetic beads. The microsensor device is provided with an array of sensor units comprising circuits for generating a magnetic field and giant magnetoresistive devices (GMR) for detecting stray fields generated by magnetized magnetic beads. The resistance of the GMR thus represents the amount of magnetic beads in the vicinity of the sensor unit. [0003] The problem with magnetic biosensors of the type described above is that the sensitivity of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/06G01N33/543G01N35/00G01R33/09G01R33/12
CPCG01R33/12G01N27/745G01N35/0098
Inventor H·杜里克
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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