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Composition for treating cardiovascular disease and preparation thereof

A composition and cardiovascular technology, applied in the field of preparation of compositions and their injection preparations, can solve problems such as imperfect quality standards, unclear active ingredients, precipitation, etc.

Inactive Publication Date: 2009-03-04
巩洪刚 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Shenmai injection has been widely used in the clinical treatment of cardiovascular and respiratory diseases. The existing Shenmai injection preparations have unstable quality, which is mainly because they are only obtained after extraction, simple refining, liquid preparation, encapsulation and sterilization. Chinese herbal medicine extracts contain a large amount of impurities such as kerosene, pigments, bacterial heat sources, etc. After a long time of storage, problems such as darkening of color, precipitation, and content reduction will occur. Moreover, the active ingredients in the preparation are not clear, and the quality standards are not perfect. There are large differences in batch quality, which affects the exact, stable and standardized production of injections

Method used

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  • Composition for treating cardiovascular disease and preparation thereof
  • Composition for treating cardiovascular disease and preparation thereof
  • Composition for treating cardiovascular disease and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Red ginseng saponin 100g Ophiopogon saponin 10g Mannitol 100g Water for injection 1000ml

[0145] Among them, red ginseng saponin extract is calculated as dry product, containing ginsenoside Rg 1 Not less than 10.0%, not less than 3.6% of ginsenoside Re, ginsenoside Rb 1 Not less than 12.6%, the total ginsenoside content not less than 80%;

[0146] Among them, the extract of Ophiopogon japonicus saponins is calculated on the basis of dry product, containing no less than 8.0% of Ophiopogon japonicus saponin D', no less than 8.0% of Ophiopogon japonicus saponin D', and no less than 80% of Ophiopogon japonicus total saponins;

[0147] Take the prescribed amount of red ginseng saponin and Ophiopogon japonicus saponin, add it to 300-500ml water for injection under sterile conditions, add 10% NaOH solution to adjust the pH value to 7-8, make it fully dissolved, add 0.02% activated carbon to absorb heat source, add Dilute to 1000ml with water for injection, filter with 0.22u...

Embodiment 2

[0149] Red ginseng saponin 10g, Ophiopogon japonicus saponin 1g, Ophiopogon japonicus flavone 0.8g, Mannitol 100g, Water for injection 1000ml

[0150] Take the prescribed amount of red ginseng saponin, radix radix saponin, and radix radix flavonoids, add them to 300-500ml of water for injection under sterile conditions, add 10% NaOH solution to adjust the pH value to 7-8, fully dissolve, add 0.02% activated carbon for adsorption In addition to pyrogens, add water for injection to dilute to 1000ml, filter through a 0.22um microporous membrane, pack in vials, each bottle contains 1ml, freeze-dry at low temperature for 24-36 hours, and package under sterile conditions.

Embodiment 3

[0152] Ophiopogon japonicus saponin 1g, Ophiopogon japonicus flavone 0.8g, Mannitol 100g, Water for injection 1000ml

[0153] Take the prescribed amount of Ophiopogon japonicus saponins and Ophiopogon japonicus flavonoids, add them to 300-500ml water for injection under sterile conditions, add 10% NaOH solution to adjust the pH value to 7-8, fully dissolve, add 0.02% activated carbon to absorb heat source, add Dilute to 1000ml with water for injection, filter with 0.22um microporous membrane, pack in vials, each bottle contains 1ml, freeze-dry at low temperature for 24-36 hours, and package under aseptic conditions.

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Abstract

The invention discloses a composition for treating cardiovascular diseases and a preparation method thereof. The composition comprises (by weight part) Radix Ginseng Rubra saponin 2-20, Ophiopogon japonicus saponin 0.2-3, and Ophiopogon japonicus flavone 0.02-3; wherein the Radix Ginseng Rubra saponin extract contains (by dry weight) ginsenoside Rg1 not less than 9.0%, ginsenoside Re not less than 3.0%, ginsenoside Rb1 not less than 12.0%, and Panax ginseng total saponins not less than 80%; the Ophiopogon japonicus saponin extract contains (by dry weight) ophiopogonin D not less than 6.0%, ophiopogonin D' not less than 6.0%, and Ophiopogon japonicus total saponins not less than 80%; and the Ophiopogon japonicus flavone extract contains (by dry weight) methylophiopogonone A and methylophiopogonone B in total not less than 80%. Animal experiments showed that the composition has good therapeutic action on myocardial ischemia and has better anti-shock effect.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a composition of chemical components for treating cardiovascular diseases and a preparation method thereof for injection preparations. Background technique [0002] Shenmai Injection is a traditional Chinese medicine preparation successfully developed with modern science and technology on the basis of the ancient prescription Shenmai Drink. It is refined from red ginseng and Ophiopogon japonicus. The functions of blood stasis, regulating qi and resuscitating. Among them, ginseng has the effect similar to cardiac glycosides, which can enhance myocardial contractility, dilate coronary arteries, and improve microcirculation; Ophiopogon japonicus can promote humoral immunity and regulate nucleic acid metabolism; combined use can strengthen the heart, dilate blood vessels, and regulate neuroendocrine functions. effect. Experimental studies have shown that its pharmacological effects are mainly...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K31/7048A61P9/10A61K31/352A61K31/704
Inventor 马振元巩洪刚
Owner 巩洪刚
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