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Preparation and use of I -type collagen artificial tendon, ligaments

A technology for artificial tendons and ligaments, applied in the medical field, can solve problems such as ineffective effects and impossible to prevent adhesions, etc.

Active Publication Date: 2008-12-31
许和平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the clinical application of hormones, some biological agents and some surgical treatment methods have no obvious effect, can not effectively regenerate and repair tendons and ligaments, and cannot prevent the formation of adhesions

Method used

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  • Preparation and use of I -type collagen artificial tendon, ligaments
  • Preparation and use of I -type collagen artificial tendon, ligaments
  • Preparation and use of I -type collagen artificial tendon, ligaments

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of artificial tendons or ligaments

[0025] Use 98% pure type I collagen to make a 0.5% concentration collagen suspension, and place it in a vessel containing 1-0 sutures at a low temperature of -60 degrees Celsius to make a 1.0 mm diameter and 10 mm long column. Collagen body, type I collagen artificial ligament or tendon with pores of 80 μm with fixed sutures.

Embodiment 2

[0026] Example 2: Preparation of artificial tendons or ligaments

[0027] Use 98% pure type I collagen to make a 0.5% concentration of collagen suspension. Place a vessel containing 6-0 sutures at a low temperature of -100 degrees Celsius to make an inner diameter of 10 mm and 150 mm. Long columnar collagen body, type I collagen artificial ligament or tendon with fixed sutures with pores of 200μm.

Embodiment 3

[0028] Example 3: Preparation of artificial tendons or ligaments

[0029] Use 98% pure type I collagen to make a 0.5% concentration of collagen suspension. Place a vessel containing 3-0 sutures at a low temperature of -80 degrees Celsius to make an inner diameter of 5 mm and 125 mm. Long columnar collagen body, type I collagen artificial ligament or tendon with fixed sutures with pores of 125μm.

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Abstract

The invention provides a medical collagen material, a manufacturing method and the application of the medial collagen material. The medical collagen material is provided with a prismatic artificial ligament / hamstring tendon with seams and a platy film provided with dense pores. The artificial prismatic ligament / hamstring tendon is provided with the longitudinal pore that is specifically sized. The artificial prismatic ligament / hamstring tendon and the platy film are used for connecting and wrapping injured sutured part. The medical collagen material has the characteristics of stable structure, good biocompatibility and the ability of degradation and absorption and can reduce or prevent tissue adhesion.

Description

Technical field [0001] The invention relates to the technical fields of medicine, medical biomaterials, and medical tissue engineering, and specifically relates to an artificial tendon and ligament built-in replacement after tendon and ligament injury and defect, so as to regenerate normal tendon / ligament tissue. At the same time, it provides a preparation and application of an artificial tendon and ligament complex for preventing postoperative tissue adhesion. Background technique [0002] At the end of the 20th century, with the rapid development of holistic medicine, cell biology, molecular biology, genetics and tissue engineering also continued to advance and develop. Biomaterials with good properties are also quickly discovered and utilized. The rapid development of tissue engineering in medical clinics in recent years has proved this point. Tissue engineering products that use type I collagen as a scaffold for tissue repair and regeneration have gained significant developme...

Claims

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Application Information

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IPC IPC(8): A61F2/08A61L27/24
Inventor 许和平
Owner 许和平
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