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Head degenerative disease detection method, detecting program, and detector

一种变性疾病、检测方法的技术，应用在测量装置、辐射的测量、诊断记录/测量等方向，能够解决诊断灵敏度低等问题

Inactive Publication Date: 2008-12-10
NIHON MEDI PHYSICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the diagnostic method based on clinical observation, the diagnostic sensitivity at the early stage of the disease is low, and the diagnostic result under this diagnostic method is easily affected by the recognition ability that an individual is born with

Method used

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  • Head degenerative disease detection method, detecting program, and detector
  • Head degenerative disease detection method, detecting program, and detector
  • Head degenerative disease detection method, detecting program, and detector

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] The following examples are given to illustrate the present invention in more detail, but the present invention is not limited to these examples.

[0103] (setting of area of ​​interest)

[0104] The head PET images produced by using FDG of 20 cases of healthy people were used as normal group (hereinafter referred to as normal A group), and 20 cases were used in NINCDS / ADRDA (National Institute of Neurological and Communicative Disorders and Strokes-Alzheimer's Disease and Related Disorders Association) head PET images of patients diagnosed as "probable" (basically diagnosed as geriatric diseases) under the diagnostic criteria of FDG were used as a disease group (hereinafter referred to as disease group A), and performed Concerned about the setting of the area.

[0105] First, anatomical standardization processing and data brain surface extraction using the NEUROSTAT program (iNEUROSTAT version2, provided by Japan Meji Fujitsu Co., Ltd.) were performed on the head PET i...

Embodiment 2

[0129] (Setting of regions of interest in the diagnosis of dementia with Lewy bodies (hereinafter referred to as DLB))

[0130] Using the head PET images of 22 cases of healthy subjects (hereinafter referred to as normal group C) produced by FDG, 10 cases of DLB ​​diagnostic criteria (MaKeith IG, Garasko D, KosakaK, et al., Consensus guidelines for the clinical and Pathological diagnosis of dementia with Lewy bodies (DLB).Neurology 1996;47:p.1113-24) PET images of the head of a patient diagnosed as "probable" (basically confirmed as DLB) due to the use of FDG (hereinafter referred to as disease Group C), and 22 patients who were diagnosed as "probable" (basically diagnosed as Alzheimer's disease) under the diagnostic criteria of NINCDS / ADRDA (National Institute of Neurological and Communicative Disorders and Strokes-Alzheimer's Disease and Related Disorders Association) due to the use of FDG The generated PET images of the head are used as disease clusters (hereinafter referre...

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PUM

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Abstract

A head degenerative disease detecting method comprising (a) standardization step of creating a first image by applying anatomical standardization to a head nuclear medical image, (b) a conversion step of creating a second image by converting the pixel value of each pixel of an image based on the first image into a z score or a t value, (c) an addition step of calculating the sum of the pixel values of the pixels in a predetermined region of interest in the second image, and (d) a detecting step of obtaining the results of the detection of the head degenerative disease by the operation of comparing the sum and a predetermined threshold.

Description

technical field [0001] The present invention relates to a method for detecting head degenerative diseases including Alzheimer's disease, a program and a device for executing the method. Background technique [0002] As the aging population increases, the number of patients with degenerative diseases accompanied by dementia, including Alzheimer's disease, will gradually increase. Early diagnosis is especially important as these diseases worsen with age and bring changes to the patient and their surrounding living environment. [0003] This degenerative disease accompanied by dementia is mainly represented by the Mini Mental Status Examination (Mini Mental Status Examination, hereinafter referred to as "MMSE"), and is diagnosed by a diagnostic method based on clinical observation such as a doctor's consultation. However, in the diagnostic method based on clinical observation, the diagnostic sensitivity at the early stage of the onset is low, and the diagnostic result under th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01T1/161A61B10/00
CPCA61B5/055A61B6/037A61B6/481G01T1/00G06T7/0012G06T2207/10104G06T2207/20104G06T2207/30016A61B5/4088A61B6/48G01T1/161
Inventor 石井一成渡边清贵三木秀哉浜田一男
Owner NIHON MEDI PHYSICS CO LTD
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