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Composition containing telmisartan and preparing method thereof

A technology for telmisartan and a composition, which is applied to the field of tablets containing telmisartan, can solve problems such as time-consuming and laborious spray drying methods, and achieve the effects of improving efficiency, mature technology and saving costs

Inactive Publication Date: 2008-12-03
上海信谊嘉华药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

What this document refers to is U.S. Patent (Appl.No.: 09 / 304,884), which adopts a relatively time-consuming and laborious spray drying method

Method used

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  • Composition containing telmisartan and preparing method thereof
  • Composition containing telmisartan and preparing method thereof
  • Composition containing telmisartan and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Telmisartan 40g

[0050] Polyvinylpyrrolidone 12g

[0051] Meglumine 12g

[0052] Sodium hydroxide 3.36g

[0053] Microcrystalline Cellulose 80g

[0054] Mannitol 90g

[0055] Cross-linked polyvinylpyrrolidone 40g

[0056] Magnesium Stearate 5g

[0057] Dissolve the above amount of telmisartan, meglumine, sodium hydroxide and polyvinylpyrrolidone in 95% ethanol-water solution (4:1) (about 110 ml) to obtain a uniform solution. Pass the above amount of mannitol, microcrystalline cellulose and cross-linked polyvinylpyrrolidone through a 60-mesh sieve, and then mix uniformly to obtain a granular mixture. The resulting particle mixture is placed in a fluidized bed and sprayed with the above homogeneous solution. The granules sprayed with the solution are dried and passed through a 24-mesh sieve for sizing, then the above-mentioned amount of magnesium stearate is added, mixed evenly, and compressed into tablets to obtain 1000 tablets of the preparation.

Embodiment 2

[0059] Telmisartan 40g

[0060] Sodium hydroxide 3.5g

[0061] Meglumine 8.5g

[0062] Polyvinylpyrrolidone (K30) 16.0g

[0063] Microcrystalline Cellulose 70g

[0064] Cross-linked polyvinylpyrrolidone 34g

[0065] Mannitol: 40g

[0066] Magnesium stearate: 5g

[0067] Dissolve the above amount of telmisartan, meglumine, sodium hydroxide and polyvinylpyrrolidone in 95% ethanol-water solution (4:1) (about 110 ml) to obtain a uniform solution. Pass the above amount of mannitol, microcrystalline cellulose and cross-linked polyvinylpyrrolidone through a 60-mesh sieve, and then mix uniformly to obtain a granular mixture. The resulting particle mixture is placed in a fluidized bed and sprayed with the above homogeneous solution. The granules sprayed with the solution are dried and passed through a 24-mesh sieve for sizing, then the above-mentioned amount of magnesium stearate is added, mixed evenly, and compressed into tablets to obtain 1000 tablets of the preparation.

Embodiment 3

[0069] Telmisartan 40g

[0070] Sodium hydroxide 6g

[0071] Meglumine 12g

[0072] Polyvinylpyrrolidone (K30) 8.0g

[0073] Microcrystalline Cellulose 80g

[0074] Cross-linked polyvinylpyrrolidone 40g

[0075] Mannitol 14g

[0076] Magnesium stearate 0.2g

[0077] Dissolve the above amount of telmisartan, meglumine, sodium hydroxide and polyvinylpyrrolidone in 95% ethanol-water solution (4:1) (about 110 ml) to obtain a uniform solution. Pass the above amount of mannitol, microcrystalline cellulose and cross-linked polyvinylpyrrolidone through a 60-mesh sieve, and then mix uniformly to obtain a granular mixture. The resulting particle mixture is placed in a fluidized bed and sprayed with the above homogeneous solution. The granules sprayed with the solution are dried and passed through a 24-mesh sieve for sizing, then the above-mentioned amount of magnesium stearate is added, mixed evenly, and compressed into tablets to obtain 1000 tablets of the preparation.

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Abstract

The invention provides a medicine composition, which comprises 100 weight portions of telmisartan, 25 to 45 weight portions of alkaline reagents, 15 to 40 weight portions of polyvinylpyrrolidone, and pharmacologically acceptable carriers. The invention also provides a preparation method for the medicine composition.

Description

technical field [0001] The present invention relates to a composition containing telmisartan, more particularly to a tablet containing telmisartan. Background technique [0002] Telmisartan is a specific angiotensin II receptor (AT type I) antagonist, mainly for the treatment of essential hypertension. Telmisartan tablets are new products developed by Boehringer Ingelheim, Germany, with a trade name of Micardis and a preparation specification of 40mg / 80mg / tablet. Mecasu was launched in the United States for the first time in 1999 for the treatment of hypertension, in 2000 in the UK, and in 2002 in my country. [0003] After inquiry, the more representative patents and related articles on the preparation of telmisartan preparations so far mainly include the following two articles: [0004] Document 1: Chinese Patent 03822605.7 "Solid Pharmaceutical Preparation Containing Telmisartan", inventors Nakatani Gaku; Oki Toshimitsu, etc. [0005] Document 2: "Study on the preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4184A61K47/34A61K47/18A61K47/02A61K9/20A61P9/12A61K47/32
Inventor 徐欣乌旭琼
Owner 上海信谊嘉华药业有限公司
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