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Cellooligosaccharide-containing composition

一种纤维寡糖、组合物的技术，应用在耐热,油性也优异，能够解决影响肠内细菌等问题，达到提高屏障功能、提高脂质代谢性、促进恢复的效果

Inactive Publication Date: 2008-09-24
ASAHI KASEI KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the problem with it is that the inhibitory effect of antibiotics is not only against pylori but also affects the intestinal bacteria that are useful to the human body
However, the crystallization treatment using a poor solvent in this document is only to improve the purity of cellobiose, and there is no description of the crystal form of cellooligosaccharides. There are completely different technologies for adjusting the crystal form and powder physical properties of fluidity and uniform dispersion

Method used

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Examples

Experimental program
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Effect test

manufacture example 1

[0250] Tricoderma reesei (Tricoderma reesei) NBRC31329 was inoculated in ordinary agar medium, and after culturing at 37°C for 7 days, spores of 1 inoculation loop were taken from the surface of the medium, and inoculated into the solution by suspending and dissolving in a total of 1 L of purified water. 1g polypeptone, 0.5g yeast extract, 2g potassium dihydrogen phosphate, 1.5g ammonium sulfate, 0.3g magnesium sulfate, 0.3g calcium chloride, 1mL trace elements (6mg boric acid, 26mg ammonium molybdate 4 hydrate, 100mg chloride Iron oxide hexahydrate, 40 mg of copper sulfate 5 hydrate, 8 mg of manganese sulfate 4 hydrate, 200 mg of zinc sulfate 7 hydrate dissolved in a total of 100 mL of purified water), 1 mL of ADEKANOL (a thickener) and In a culture medium obtained with 10 g of crystalline cellulose (manufactured by Asahi Kasei Chemical Co., Ltd., trade name PH-101), culture was carried out at 28° C. for 5 days with aeration and stirring. During the cultivation process, the p...

Embodiment 1

[0255] 100 mL of the cellooligosaccharide aqueous solution obtained in Production Example 1 was introduced into a 200 mL glass flask, and cooled from 70° C. to 25° C. at a rate of 10° C. per hour while stirring (the solubility parameter δ of the solvent was 22.2). Filter the cellooligosaccharide crystallized from the aqueous solution at 25°C under reduced pressure, dry it with a ventilated dryer at 40°C, pulverize it with a mortar, sieve it with a sieve with a mesh of 150 μm, and sieve the powder with a mesh Fine powder was removed through a 45 μm sieve to obtain cellooligosaccharide powder. 500 mg of the obtained cellooligosaccharide powder was introduced into a Φ1.1 mm steel cylindrical socket, and pressed at 150 MPa for 10 seconds using a Φ1.1 mm flat pestle to measure the hardness of the obtained molded body. (The average L / D is 1.7, the bulk density is 0.43g / mL, the cellobiose content is 99% by mass, the cellotriose-cellohexaose content is 0.1% by mass, the glucose conten...

Embodiment 2

[0257] Using commercially available cellobiose (manufactured by Aldrich, with a purity of 98% by mass), it was dissolved in 70°C water at a concentration of 30% by mass in a 200mL glass flask so that the total amount was 100mL, and the temperature was increased at 10°C per hour. After cooling from 70°C to 25°C, add an isopropanol / ethanol solution with a volume mixing ratio of 50 / 50 at a rate of 10 g per minute so that its concentration relative to water is 50% by mass, at a rate of 10°C per hour Cooling rate from 70°C to 25°C (solubility parameter δ of the solvent is 16.6). The cellooligosaccharide crystallized in the aqueous solution was filtered under reduced pressure, dried, pulverized, and sieved in the same manner as in Example 1 to obtain a cellooligosaccharide powder. About the obtained cellooligosaccharide, the molded body hardness was measured similarly to Example 1. (The average L / D is 2.3, the bulk density is 0.54g / mL, the cellobiose content is 99% by mass, the cel...

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Abstract

Disclosed is a cellooligosaccharide composition comprising, as the main ingredient, at least one cellooligosaccharide selected from the group consisting of cellobiose, cellotriose, cellotetraose, cellopentaose and cellohexaose, which is in the powdery form having an average L / D value of 3.0 or lower, a bulk density of 0.80 g / mL or lower and an angle of repose of 60 DEG or lower.

Description

technical field [0001] In the field of internal medicine of foods and pharmaceuticals, the present invention provides a composition containing cellooligosaccharides for preventing or improving lifestyle-related diseases, which suppresses the reduction of blood adiponectin concentration by regulating the sugar composition Oral administration of fiber oligosaccharides can reduce the concentration of neutral fat and total cholesterol in the liver. The present invention also provides a cellooligosaccharide-containing composition having intestinal bacterium-activating ability to selectively activate useful bacteria without being assimilated by harmful intestinal bacteria. The present invention also provides a cellooligosaccharide-containing composition having inhibitory effect on the proliferation of pylori or bacteriostasis. [0002] In addition, in the fields of cosmetics, pharmaceuticals, and quasi-drugs, the present invention provides a composition containing cellooligosacchar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7016A61K8/73A61K9/06A61K9/08A61K9/10A61K9/16A61K9/20A61K31/702A61K47/26A61P3/04A61P3/06A61Q19/00C07H3/04C07H3/06A23L29/262
CPCA61Q19/007A61K8/731A23V2002/00A61K8/60A61K31/702A61K31/7016A23L1/3082A23L1/0534A61K8/022A23L29/262A23L33/24A61P1/04A61P1/14A61P17/00A61P17/16A61P19/10A61P3/00A61P3/14A61P31/04A61P3/04A61P3/06A61P43/00A23V2200/3204
Inventor 山崎有亮伊吹一郎柳沼义仁田村幸永
Owner ASAHI KASEI KK
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