Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hypericum extract, its making method and medicinal composition and use for treating diabetes

A technology of St. John's wort and St. John's wort, which is applied in drug combinations, metabolic diseases, and pharmaceutical formulations, and can solve problems such as weakening sleep, increasing anesthetics to induce sleep, and not being suitable for combined use.

Inactive Publication Date: 2008-09-17
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
View PDF0 Cites 19 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0042] Drug Interactions: Animal experiments show that Hypericum perforatum can significantly increase the sleep induced by anesthetics and antagonize the effect of reserpine; some animal experiments have found that it can weaken the sleep induced by barbiturates; clinical use of 5-HT There is a risk of 5-HT syndrome when taking drugs, which is rare but fatal, so Hypericum perforatum should not be used in combination with other antidepressants with similar effects to avoid the above risks

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hypericum extract, its making method and medicinal composition and use for treating diabetes
  • Hypericum extract, its making method and medicinal composition and use for treating diabetes
  • Hypericum extract, its making method and medicinal composition and use for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Example 1. Water extract

[0078] Hypericum perforatum L. (Hypericum perforatum L.) whole herb with flowers 100g, heat reflux with 500ml of distilled water, extract three times (500ml / time), extract 1-1.5 hours each time, extract under reduced pressure and concentrate to get water extract 26.0 g, dissolved in 50ml of water, added ethanol until the alcohol content reached 70% (volume ratio), precipitated, filtered, and concentrated the filtrate to dryness to obtain 21.0 g of a yellow powdery solid.

[0079] The filtrate part is separated by macroporous resin column:

[0080] 20.0 g of the filtrate was dissolved in 100 ml of water, added to a 200 g macroporous resin column (AB-8), washed with distilled water until the effluent was colorless, then eluted with ethanol until the effluent was colorless, and the ethanol eluted part was concentrated 4.5g was obtained. The macroporous resin is washed with water until the effluent is alcohol-free (macroporous resin regeneration...

Embodiment 2

[0081] Example 2. Alcoholic extract

[0082] Hypericum perforatum (Hypericum perforatum L.) whole herb 2500g, heat reflux with 95% EtOH, extract three times (7.5 liters of 95% EtOH / time), slowly heat to boiling, extract for 1-2 hours each time, and concentrate the extract under reduced pressure Afterwards, 610.0 g of 95% EtOH extract was obtained, suspended in 1500 ml of water, filtered, and the filtrate was extracted three times with ethyl acetate (1500 ml / time), the extracts were combined, and the solvent was recovered under reduced pressure to obtain 260.0 g of a red powdery solid.

Embodiment 3

[0083] Example 3. Ethyl acetate extract

[0084] Hypericum perforatum (Hypericum perforatum L.) whole herb 1000g, heated to reflux with 5000ml of petroleum ether, extracted three times, 1 hour each time, the extract was concentrated under reduced pressure to obtain 56.0g of petroleum ether extract; 5000 ml of the ester was heated to reflux, extracted three times, each extraction was 1 hour, the extracts were combined, and the solvent was recovered under reduced pressure to obtain 65.0 g of ethyl acetate extraction fraction.

[0085] Ethyl acetate extraction part is separated by macroporous resin:

[0086] 65.0 g of the filtrate was dissolved in 1000 ml of water, filtered, and the filtrate was added to a 1000 g macroporous resin column (S-8), washed with distilled water until the effluent was colorless, then eluted with ethanol until the effluent was colorless, washed with ethanol The part was concentrated to obtain 13.0 g. The macroporous resin is washed with water until the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses hypericum L and the extraction and the preparation method of the extraction; the drug combination containing hypericum L and / or the extraction of the hypericum L; the usage of hypericum L and / or the extraction of the hypericum L used as drugs and health care product, in particular to the usage used for preparing drugs and health care products treating and preventing metabolic disorders relative to insulin resistance, diabetes and complicating disease and other diseases.

Description

Technical field: [0001] The present invention relates to extracting an extract capable of increasing insulin sensitivity from a plant of the genus Hypericum (Hypericum L), a preparation method of the extract, and a pharmaceutical combination containing a plant of the genus Hypericum (Hypericum L) or an extract of the genus and Hypericum L) or the genus extract and its pharmaceutical composition as medicine, especially for the preparation of treatment and prevention of insulin resistance and its related metabolic diseases and diabetes and its complications medicines and health products. Background technique [0002] Insulin resistance (IR) refers to the decreased sensitivity and (or) responsiveness of the body to insulin, which is the main pathophysiological basis of metabolic syndrome such as diabetes mellitus. Insulin resistance is closely related to clinical abnormalities such as impaired glucose tolerance, type 2 diabetes, obesity, dyslipidemia, non-alcoholic fatty liver...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/38A61P5/50A61P3/10
Inventor 吉腾飞叶菲苏亚伦田金英陶荣亚冯孝章王爱国杨建波丛维娜叶峰刘倩
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com