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Method for preparing embolism-extinguishing enteric-coated capsule

An enteric-coated capsule and uniform mixing technology, applied in the field of medicine, can solve the problems of inactive lumbrokinase, incomplete extraction of active ingredients, influence on the effect of drug treatment, etc., and achieve the effect of improving the treatment effect and complete extraction.

Active Publication Date: 2008-08-13
三门峡赛诺维制药有限公司
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AI Technical Summary

Problems solved by technology

The drug extracts in Xiaoshuan Oral Liquid and Xiaoshuan Granules are extracted by using the traditional water decoction method, and the active ingredients are not extracted completely. At the same time, the protein extracted by the method of water decoction has been denatured, and its lumbrokinase No biological activity, affecting the therapeutic effect of the drug

Method used

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Examples

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Effect test

Embodiment Construction

[0006] Take the preparation of 100 kg Xiaoshuan enteric-coated capsules as an example.

[0007] Example 1. After mixing 420 kg of Chinese medicine Astragalus, 48 ​​kg of Angelica and 20 kg of Ligusticum chuanxiong, add three times the amount of 70% ethanol, soak for 1 hour, and then heat to reflux for 2 hours each time, filter separately, and combine the filtrate. First, the filtrate was concentrated under reduced pressure at a temperature of 50°C to a relative density of 1.2g / ml for later use, and then the filtered dregs, 42 kg of Chinese red peony root, 24 kg of peach kernels, and 24 kg of safflower were decocted in water for three times. After 2 hours, filter separately, combine the filtrate, concentrate the filtrate under reduced pressure to a relative density of 1.1g / ml, then add 4 times the amount of 95% ethanol to the concentrate, stir and let stand. After releasing the supernatant, reduce Press and concentrate to a relative density of 1.1g / ml for later use. Mix the above t...

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PUM

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Abstract

The invention discloses the preparation method of a medicine anti-plug enteric soluble capsule for curing anemic apoplexy, deficiency of vital energy and blood stasis. The Chinese medicines astragalus root, angelica and rhizoma ligustici wallichii are steeped into ethanol, the ethanol return flows twice, then is filtered; the filtrate is condensed at certain temperature; the dregs of a decoction are decocted in water with Chinese medicine rot of peony, semen persicae and safflower, then the liquid is filtered; the filtrate is condensed, and the concentrated solution is added by ethanol, stirred and standing; a supernatant fluid is given out and is carried on decompression condensation. Two condensates above are mixed and dried, then grinded so that an extractive is obtained; a fresh lumbricus is dried in shade and grinded, then steeped into water, an extract solution is obtained, decentered, condensed, a condensate is obtained, dried in vacuum at a certain temperature then grinded so that a lumbricus extract is obtained; the extract above is mixed with the lumbricus extract, then packed into the enteric soluble capsule. The effective ingredient of the Chinese medicine of the invention is extracted entirely, and the biological activity of the lumbrokinase of the lumbricus is kept so that the curing effect of the medicine is improved.

Description

Technical field [0001] The invention relates to a preparation method of a medicine for treating ischemic apoplexy due to deficiency of qi and blood stasis, in particular to a preparation method of antithrombotic enteric-coated capsules, belonging to the technical field of medicine. Background technique [0002] At present, there are many drugs for the treatment of ischemic stroke with deficiency of qi and blood stasis. The commonly used dosage forms are Xiaoshuan Oral Liquid and Xiaoshuan Granules. The production method of Xiaoshuan oral liquid is generally to decoct the traditional Chinese medicine Astragalus, Angelica, Chuanxiong, Red peony root, peach kernel, safflower, and Dilong three times with water, combine the decoction, filter, and concentrate the filtrate under reduced pressure and add ethanol. Leave it to stand, take the liquid, recover the ethanol, concentrate the liquid, dilute with water, add sweeteners and preservatives, mix well, potting, and sterilizing. The pro...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61K9/48A61P9/10A61P7/02A61K35/64A61K35/62
Inventor 赵占武刘黎明屈志莲贺航运张少杰刘守志连亚丽关静
Owner 三门峡赛诺维制药有限公司
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