Method of conjugating aminothiol containing molecules to vehicles

Abstract

The present invention relates to a new chemical process that provides novel carrier derivatives as excellent 1,2-aminothiol or 1,3-aminothiol specific reagents for use in For conjugation with unprotected targeting compounds (such as polypeptides, peptides or organic compounds) with or modified to have 1,2-aminothiol or 1,3-aminothiol groups. The invention also relates to methods of using the novel water-soluble polymer derivatives and conjugates thereof.

Description

[0001] This application claims priority to U.S. Application No. (not yet assigned), filed January 23, 2006, and claims the benefit of U.S. Provisional Application No. 60 / 646,685, filed January 24, 2005, which is incorporated by reference to this article. Background of the invention [0002] Recent advances in biotechnology have enabled the large-scale production of biomolecules, such as therapeutic proteins, peptides, antibodies and antibody fragments, which can now be produced on a large scale, enabling a wide range of applications of such biomolecules. Unfortunately, rapid proteolytic degradation of biomolecules, short circulatory half-lives, low solubility, instability during production, storage, or administration, or immunogenicity after administration often limit their applications. Because of the growing interest in the therapeutic and / or diagnostic use of administered biomolecules, various approaches to overcome these drawbacks have been investigated. [0003] One of t...

AI Technical Summary

Problems solved by technology

Quantification of these individual entities is generally difficult and sometimes impossible, and technical difficulties combined with insufficient existing tools can greatly hinder, or even completely prevent, the development of such biomolecules

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