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Ultrasound monitoring and feedback for magnetic hyperthermia

A technology of ultrasonic and magnetic hyperthermia, which is applied in the field of ultrasonic measurement technology to monitor and control magnetic hyperthermia, which can solve the problems of not being able to know in advance the appropriate time to start the magnetic field, making it difficult to determine, and difficult to judge the targeting agent.

Inactive Publication Date: 2008-07-30
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Difficult to tell if enough targeting agent is being obtained at a particular instantaneous time, and therefore difficult to determine if enough magnetic particles are accumulating at the desired location to achieve the desired thermal therapy
Therefore, the proper time to activate the magnetic field cannot be known in advance

Method used

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  • Ultrasound monitoring and feedback for magnetic hyperthermia
  • Ultrasound monitoring and feedback for magnetic hyperthermia
  • Ultrasound monitoring and feedback for magnetic hyperthermia

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Embodiment Construction

[0020] As described in one or more exemplary embodiments, the present specification discloses a method and apparatus for ultrasound-based monitoring of magnetic hyperthermia treatment, particularly temperature rise distribution and associated accumulated thermal dose in diseased tissue . It is well known that temperature affects the ultrasonic properties of mammalian tissue, including but not limited to the velocity, attenuation, and frequency-dependent scattering coefficient of sound waves. In an example embodiment, the temperature dependence is used to generate a 2D / 3D spatial map of temperature elevation in tissue. More specifically, it is possible to calculate a 2D / 3D spatial map corresponding to the heating caused by magnetic hyperthermia by applying a magnetic field. Also, the calculated temperature profile and thermal dose received are used to provide feedback to the magnetic system to adjust the exposure time, intensity, frequency and spatial location of the AC magnet...

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Abstract

A method and system of magnetic hyperthermia control using ultrasound thermometry, the method comprising: acquiring a reference set of ultrasound data corresponding to a tissue of interest (121); applying a plurality of magnetic nanoparticles (210) at the tissue of interest (121); applying an electromagnetic field based on a set of operating parameters to initiate the hyperthermia; acquiring another set of ultrasound data corresponding to the tissue of interest (121); and determining a temperature change based on the reference set of ultrasound data and the other set of ultrasound data.

Description

technical field [0001] The present invention relates to methods and systems for monitoring and controlling magnetic hyperthermia using ultrasonic measurement techniques. Background technique [0002] Heat therapy is an ancient therapy that has been used since ancient Greece. Hyperthermia is a therapy that completely heats a malignant tumor, tissue, or other tissue to preferentially kill malignant cancer cells without damaging nearby non-cancerous cells. [0003] Magnetothermal therapy uses magnetic particles (nanoparticles) such as magnetite (Fe 3 o 4 ) as an internal heating element, and the magnetic particles are heated by a time-varying magnetic field. And, in order to increase the curative effect and uniformly heat malignant tumor tissue, magnetite (magnetite) is used for magnetic microparticles including targeted magnetic particles having special affinity to the surface of malignant cancer cells by coating on the magnetic material film preparation. Using antibody-r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/40
CPCA61N1/406A61B2017/00084A61B2019/5276A61B2090/378
Inventor B·拉朱D·萨弗里
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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