Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Quality standard and test method of hoove pill and detection method

A technology of preparation and standard curve, which is applied in the field of quality standards and testing of Fuzheng Pills and its preparations, can solve the problems of no content determination indicators, few detection indicators, poor specificity, etc.

Active Publication Date: 2013-10-30
HANDAN PHARMA
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The quality standard of Yizheng Pills is recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health of the People's Republic of China". The original standard only included a color reaction identification, and the specificity was poor, and there were few detection indicators and no content determination indicators. , cannot effectively control product quality

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quality standard and test method of hoove pill and detection method
  • Quality standard and test method of hoove pill and detection method
  • Quality standard and test method of hoove pill and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1: the identification method and content determination method of pharmaceutical composition pill of the present invention

[0077] Identification: A. Get 8g of pharmaceutical composition pills of the present invention, grind finely, add methanol 70ml, sonicate for 20 minutes, filter, evaporate the filtrate to dryness, add water 35ml to dissolve the residue, extract three times with n-butanol, each time the solvent is 15ml, and combine the extracts , evaporated to dryness, the residue was dissolved in 1ml of methanol, and used as the test solution; another 7 g of Kansui control medicinal material was added, 35 ml of methanol was added, ultrasonic treatment was performed for 50 minutes, filtered, the filtrate was evaporated to dryness, and the residue was dissolved in 1 ml of methanol, as a control Medicinal material solution; according to the Chinese Pharmacopoeia 2005 edition one appendix VIB thin-layer chromatography test, absorb 0.006ml of the test product ...

Embodiment 2

[0084] Embodiment 2: the identification method and assay method of pharmaceutical composition tablet of the present invention

[0085]A. Take 20g of the tablet of the pharmaceutical composition of the present invention, grind it finely, add 60ml of ethyl acetate, extract under heat reflux for 40 minutes, filter, evaporate the filtrate to dryness, add 30ml of water to the residue to dissolve, extract three times with ethyl acetate, each solvent is 20ml , combine the extracts, evaporate to dryness, add 1ml of ethanol to the residue to dissolve, and use it as the test solution; take 3g of Gansui reference medicinal material, add 40ml of ethyl acetate, extract under reflux for 40 minutes, filter, evaporate the filtrate to dryness, add Dissolve 1ml of ethyl acetate as the reference medicinal material solution; according to the Chinese Pharmacopoeia 2005 edition, appendix VIB thin-layer chromatography test, absorb 0.01ml of the test solution and 0.005ml of the reference medicinal so...

Embodiment 3

[0091] Embodiment 3: the identification method of pharmaceutical composition oral liquid preparation of the present invention:

[0092] Take 25ml of the oral liquid preparation of the pharmaceutical composition of the present invention, add 50ml of petroleum ether with a boiling range of 60 to 90°C, extract by cold soaking for 40 minutes, filter, evaporate the filtrate to dryness, add 1ml of n-butanol to the residue to dissolve, and use it as the test solution Take another 3 g of Muxiang reference medicinal material, add 10 ml of methanol, soak in cold for 40 minutes, filter, evaporate the filtrate to dryness, add 1 ml of ethanol to the medicinal residue to dissolve, and use it as the reference medicinal material solution; Method test, draw 0.01ml of each of the above two solutions, point them on the same silica gel G thin-layer plate, use cyclohexane: acetone = 9:2 solution as developing agent, develop, take out, dry in the air, spray with 10% Sulfuric acid ethanol solution u...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an ascites pill and a quality control method for the preparation of the ascites pill, wherein the preparation is provided with a plurality of formulations by adding conventional accessories according to the ascites pill preparation formula in the second volume of traditional Chinese medicine set prescriptions preparations of Drug Standards of Ministry of Health of the People's Republic of China. The quality control method which comprises a content determination or content identification or one of the content determination and the content identification increases the thin layer identification of euphorbia Gansui Root, jujube oleanolic acid and elecampane based on the original quality standards, revises the thin layer identification of melanterite and builds the content determination for the green copperas (FeSO4 7H2O) and improves the controllability of the product quality.

Description

technical field [0001] The invention relates to a quality control method and a detection method of a pharmaceutical composition preparation, in particular to a quality control method and a detection method of a swelling pill and a preparation thereof. Background technique [0002] Jizheng Pills is a drug recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health of the People's Republic of China". It is a commonly used Chinese patent medicine in clinical practice. It has the effects of diuresis, swelling, dehumidification and invigorating the spleen. It is mainly used for symptoms such as dysentery, fullness of the chest and abdomen, edema of the limbs, constipation, and short red urine. The quality standard of Yizheng Pills is recorded in the second volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health of the People's Republic of China". The original standard only...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A61K9/20A61P1/10A61P1/14A61P7/10G01N30/90G01N21/33A61K33/26
Inventor 陈致慜李春雷霍志金李红梅刘宇
Owner HANDAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com