Compositions for the treatment of tumour
A composition and tumor technology, applied in the direction of anti-tumor drugs, drug combinations, active ingredients of heterocyclic compounds, etc., can solve the problems of unpredictable positive results and other problems
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[0145] Male adult SCID Hsd: ICR9 CD-1 mice (Harlan, Indianapolis, IN) aged 6-8 weeks were used for animal experiments. About 1×10 6 HCT116 or A549 human tumor cells (obtained directly from ATCC) were injected subcutaneously into the left and right abdomen of each animal. Monitor the tumor growth in animals, when the tumor volume reaches about 500mm 3 At time, the animals were randomly divided into treatment groups (n=10).
[0146] The composition of chlorpromazine / pentamidine (CRx-026) with a weight ratio of 1:2 was administered as an intraperitoneal bolus at a concentration of 0.97 mg / ml and 1.87 mg / ml in 5% glucose. For two weeks, or at a concentration of 23 mg / ml and 44 mg / ml, respectively, in a 5% glucose solution containing 10% ethanol, administered via an ALZET osmotic mini pump implanted intraperitoneally for two weeks. The amount administered by each method was 5 mg chlorpromazine / kg body weight and 10 mg pentamidine / kg body weight.
[0147] During the treatment, the tumor...
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