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Antigenic composite, multi-clone antibody prepared by it and its application

A polyclonal antibody and composition technology, applied in the direction of antibodies, drug combinations, allergic diseases, etc., can solve problems such as side effects, abnormal induction and regulation, and non-specific killing and clearing effects

Inactive Publication Date: 2007-12-19
徐何 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acquisition of these preparations still belongs to the old generation of polyclonal antibodies due to the use of thymocyte antigens, and these polyclonal antibody preparations are not specific to white blood cells participating in the immune reaction, but due to normal white blood cells, bystander cells Or beneficial cells have non-specific killing and clearing effect and abnormal induction and regulation, thus producing obvious side effects (Gaber AO, et al. Transplantation 1998, 66: 29-37, Guttmann RD, et al. Transplant Proc 1997, 29: 24S-26S, Su Zexuan et al. Modern Transplantation, 1998, pp. 136-145)

Method used

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  • Antigenic composite, multi-clone antibody prepared by it and its application
  • Antigenic composite, multi-clone antibody prepared by it and its application
  • Antigenic composite, multi-clone antibody prepared by it and its application

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Embodiment Construction

[0021] Definition of Terms

[0022]"Immunoglobulin" or "Ig": defined herein as a group of plasma globulin proteins that function as antibodies. Immunoglobulins include IgA, IgG, IgM, IgE, or IgD and / or subtypes thereof, such as IgG 1 , IgG 2 , IgG 3 , IgG 4 , IgA 1 , or IgA 2 . IgA functions as an essential antibody and is present in body secretions such as tears, human milk, gastrointestinal secretions, and mucus in the respiratory and genitourinary tracts. IgG functions as the most common circulating antibody.

[0023] "Polyclonal antibody": A mixture of different antibody molecules that bind and react with more than one immunogenic determinant of an antigen. The term "polyclonal antibody" in the present invention includes polyclonal antibodies isolated and purified from blood, secretions or other body fluids such as peritoneal fluid and from egg cells of mammals.

[0024] "An isolated or purified polyclonal antibody": refers to a polyclonal antibody isolated and pu...

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Abstract

The present invention relates to antigen composition comprising leukocyte and cell line mixture. The antigen composition may be animal immunized to obtain new generation of polyclonal antibody possessing specific abnormal immunity reaction preventing and treating effect. The present invention proposes immunotherapy on abnormal immunity reactions, including autoimmune diseases, implant-anti-host diseases, rejection reaction, etc. The polyclonal antibody the present invention provides acts directly on lymphocyte and monocyte to be determined to participate in the abnormal immunity reaction while having less removal and blocking on static or unactivated lymphocyte.

Description

technical field [0001] The invention relates to a composition used as an antigen to immunize animals, and the use of the antigen composition to prepare a new generation of polyclonal antibodies and the use of the polyclonal antibodies in treating and preventing abnormal immune reactions. The present invention also proposes immunotherapy for abnormal immune responses, including autoimmune diseases, graft-versus-host disease, allogeneic organ, tissue, cell transplantation rejection, heterogeneous allogeneic organ, Rejection after tissue and cell transplantation, multiple sclerosis, diabetes, etc. technical background [0002] The French biologist Bert conducted a comparative and systematic study on allografts for the first time in his 1864 study (Bert P.J Anat.Physiol 1864, 1:85). The first relatively clear affirmation that lymphocytes play a dominant role in rejection was proposed by Billingham et al. (Billingham R, et al. N.Y. Acad. Sci 1960, 87: 457) and Anderson et al. a...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P37/02
Inventor 徐何于锋刘子栋
Owner 徐何
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