Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Freeze dried injection containing muskone and preparation method thereof

A freeze-dried powder injection and freeze-dried powder injection technology are applied in the field of Xingnaojing freeze-dried powder injection and its preparation, which can solve the problems of poor drug stability and frequent adverse reactions.

Active Publication Date: 2007-12-12
HENAN NEW CENTURY PHARMA
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, some commonly used traditional Chinese medicine injections in clinical practice have poor drug stability due to various reasons, and there are frequent reports of adverse reactions, so it is necessary to further research and develop.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Freeze dried injection containing muskone and preparation method thereof
  • Freeze dried injection containing muskone and preparation method thereof
  • Freeze dried injection containing muskone and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0217] Embodiment 1: the preparation of freeze-dried powder injection

[0218] a. Take the following raw drug components in parts by weight: musk 15g, turmeric 60g, gardenia 60g, borneol 1g;

[0219] b. For the above four flavors, the turmeric is crushed into coarse particles, and the volatile oil is extracted for later use; the Gardenia jasminoides is extracted with ethanol, filtered, and the extracts are combined, the ethanol is recovered, concentrated into an extract, and the pH of the extract is adjusted with HCl, boiled, cooled, Centrifuge after refrigeration, extract the centrifugate with n-butanol, combine the n-butanol extracts, recover n-butanol under reduced pressure, concentrate, and dry to obtain the gardenia extract; musk is extracted with ethanol continuous reflux, and the extract is used for later use; borneol is crushed for later use; According to the preparation method of freeze-dried powder injection, the above-mentioned substances are prepared into freeze-dr...

Embodiment 2

[0220] Embodiment 2: the preparation of freeze-dried powder injection

[0221] a. Take the following raw material drug components in parts by weight: musk 90g, turmeric 300g, gardenia 300g, borneol 6g;

[0222] b. For the above four flavors, the turmeric is crushed into coarse particles, and the volatile oil is extracted for later use; the Gardenia jasminoides is extracted with ethanol, filtered, and the extracts are combined, the ethanol is recovered, concentrated into an extract, and the pH of the extract is adjusted with HCl, boiled, cooled, Centrifuge after refrigeration, extract the centrifugate with n-butanol, combine the n-butanol extracts, recover n-butanol under reduced pressure, concentrate, and dry to obtain the gardenia extract; musk is extracted with ethanol continuous reflux, and the extract is used for later use; borneol is crushed for later use;

[0223] Take hydroxypropyl-β-cyclodextrin, add water to dissolve, take the turmeric volatile oil and add it dropwise...

Embodiment 3

[0224] Embodiment 3: Preparation of freeze-dried powder injection

[0225] a. Take musk 37.5g, turmeric 150g, gardenia 150g, borneol 5g;

[0226] b. The above four flavors and turmeric are crushed into coarse particles, and the volatile oil is extracted for later use; Gardenia is extracted 5 times with 14 times the amount of 99.5% ethanol under reflux, each time for 1 hour, filtered, combined extracts, the filtrate is decompressed to recover ethanol, and When concentrated to 50°C, the relative density is about 1.10 to 1.25. The extract is adjusted to a pH of 1 to 4 with HCl, boiled for 3 hours, cooled, refrigerated for 36 hours, centrifuged, and the centrifuged liquid is extracted 8 times with n-butanol. Combine n-butanol extracts, recover n-butanol under reduced pressure, concentrate to an extract with a relative density of about 1.10-1.35 (50°C), and dry to obtain Gardenia jasmine extract; musk is extracted with 8 times the amount of 99.5% ethanol under reflux 6 hour, the e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a freeze-dried powder injection containing musk ketone for treating apoplexy, which is prepared from Chinese herbs including musk, curcuma aromatica, cape jasmine and borneol through extraction processes.

Description

technical field [0001] The invention relates to a Xingnaojing freeze-dried powder injection and a preparation method thereof, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Ischemic stroke, accounting for 53.6% of stroke, is mainly caused by thrombosis on the basis of cerebral atherosclerosis (ie, cerebral infarction). With the in-depth understanding of the pathophysiological process of ischemic stroke and the improvement and development of new treatment methods, the concept of "brain attack" has been paid more and more attention. Every hour of initial ischemia and brain tissue damage will rapidly increase the degree of irreversible brain damage, and more and more people realize that stroke is a disease similar to myocardial infarction that also requires emergency treatment. In recent years, based on the concept of "treatment time window", a reasonable treatment plan has been formulated within a certain period of time afte...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/9066A61K9/19A61P9/10A61P7/02A61K31/122A61K31/7048A61K31/045
Inventor 叶正良李永强郑永锋李瑞明
Owner HENAN NEW CENTURY PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com