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Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis

A technology of pulmonary fibrosis and palm ginseng, which is applied in the field of traditional Chinese medicine extracts and preparation of drugs for the treatment of pulmonary fibrosis, can solve the problems of large side effects and poor curative effect

Inactive Publication Date: 2010-05-12
LOGISTICS UNIV OF CAPF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs used clinically for the treatment of pulmonary fibrosis have disadvantages such as large side effects and poor curative effect. It is very urgent and important to develop new drugs for the treatment of pulmonary fibrosis.

Method used

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  • Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis
  • Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis
  • Gymnadenia conopsea extraction and its application in preparing medicine for treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of ginseng extract, made by following method:

[0017] Ginseng palm crude drug is pulverized and sieved, soaked in 60% ethanol aqueous solution with volume percentage concentration 8 times of the weight of said palm ginseng crude drug powder for 24 hours, heated and refluxed for 2 hours, filtered, extracted 2 times, combined filtrate, and filtrate reduced The relative density is 1.05 when concentrated under pressure to 50 DEG C, promptly makes a kind of palm ginseng extract.

Embodiment 2

[0019] A kind of ginseng extract, made by following method:

[0020] Ginseng palm crude drug is pulverized and sieved, soaked in 70% ethanol aqueous solution with a volume percentage concentration 4 times the weight of the palm ginseng crude drug powder for 18 hours, heated and refluxed for 3 hours, filtered, extracted once, combined filtrate, and filtrate reduced The relative density is 1.2 when concentrated under pressure to 50 DEG C, promptly makes a kind of palm ginseng extract.

Embodiment 3

[0022] A kind of ginseng extract, made by following method:

[0023] Ginseng palm crude drug is pulverized and sieved, soaked in 50% ethanol aqueous solution with volume percentage concentration 10 times of the weight of said palm ginseng crude drug powder for 30 hours, heated and refluxed for 0.5 hour, filtered, extracted 3 times, combined filtrate, filtrate reduced The relative density is 1.1 when concentrated under pressure to 50 ℃, promptly makes a kind of palm ginseng extract.

[0024] Various pulmonary interstitial diseases (such as silicosis) and pulmonary fibrosis caused by collagen diseases have a similar pathological process: starting from alveolitis, leading to pulmonary fibrosis in the process of development and excessive repair. The present invention adopts rat tracheal exposure method to inject silica dust (50mg / only) to cause silicosis animal model, rats are divided into four groups at random, i.e. control group, silica dust group, palm ginseng treatment group, ...

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Abstract

The present invention discloses one kind of conic gymnadenia tuber extract and its application in preparing medicine for treating pulmonary fibrosis. The conic gymnadenia tuber extract is prepared through crushing conic gymnadenia tuber, sieving to obtain conic gymnadenia tuber powder, soaking the conic gymnadenia tuber powder in 50-70 % concentration alcohol water solution of 4-10 time volume for18-30 hr, heating reflux to extract for 0.5-3 hr, filtering, repeating the extraction step for 1-3 times, merging the filtrate, decompression concentrating to density at 50 deg.c of 1.05-1.2. Experiment proves the treating effect of the conic gymnadenia tuber extract on pulmonary silicosis, and this reveals its use value in treating other pulmonary fibrosis diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine extract and its application in preparing medicine for treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis is a disease characterized by diffuse alveolitis and alveolar structural disturbances that eventually lead to pulmonary interstitial fibrosis. Pulmonary fibrosis can be caused by various factors such as bacteria, dust, radioactive material, trauma, and drugs. Due to the high incidence rate and low cure rate of pulmonary fibrosis, it has become a disease that seriously endangers people's health due to the lack of effective therapeutic drugs. For example, pneumoconiosis, a disease that can cause pulmonary fibrosis, is a major occupational disease in my country. Since the 1950s, more than 580,000 pneumoconiosis cases have been reported in my country, more than 140,000 people have died, and more than 440...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P11/00A61K125/00
Inventor 王世鑫汪骏曾锦波
Owner LOGISTICS UNIV OF CAPF
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