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Application for extration of glossy ganoderma in preparing medicine and health products for treating and improving depression symptoms a variety of causes resulting sleep disorder

A Ganoderma lucidum extract and a technology for the extract are applied in the application field of Ganoderma lucidum extract in the preparation of medicines and health care products for treating and improving depression symptoms and sleep disorders caused by various reasons, so as to achieve the effect of improving sleep disorders

Inactive Publication Date: 2007-11-28
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the antidepressant effect of Ganoderma lucidum extract and the improvement of sleep disorders caused by various factors.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0012] Experimental example one. Effects of Ganoderma lucidum extract on pentobarbital sodium-induced sleep duration in chronic unpredictable stress mice.

[0013] experiment method:

[0014] Establishment of chronic unpredictable stress model and experimental methods: Stimuli include: forced swimming (10°C, 6min), tail clamping (1cm from tail root, 1min), water deprivation (24h), fasting (24h), loneliness Feeding (24h), tail suspension (1h), braking (2h), high-speed horizontal shock (120 times / min, 1h), plantar electric shock for 45min (average 1mA, duration 1s, 1 time / 1min). The chronic stress course was 21 days in total, once a day, and a stimulation method was randomly selected for stimulation. Time: between 9:00 am and 2:00 pm. 60 minutes before stress every day, animals in each group were given Ganoderma lucidum extract (240 mg / kg, p.o.), double distilled water (blank group and stress control group) or imipramine (14 mg / kg, i.p.) according to body weight. On the 22nd...

experiment example 2

[0018] Experimental example two. The effect of Ganoderma lucidum extract on the swimming immobility time of rats with chronic unpredictable stress The establishment of chronic unpredictable stress model and the experimental method are the same as above.

[0019] The immobility of rats in the forced-swim model mirrors the animal's desperation behavior and mimics the depressive state in humans. The forced swimming test was performed on the 22nd day of the chronic stress test, and the test results are shown in Table 2. Compared with the normal control group, the immobility time of the rats in the stress group increased significantly (P<0.01), indicating that the depression model has been established. Ganoderma lucidum extract (240 mg / kg, p.o.) and fluoxetine (15 mg / kg, p.o.) could significantly reduce (P<0.001) the swimming immobility time of rats after 21 days of stress. It is suggested that Ganoderma lucidum extract can improve the hopeless behavior of depression.

[0020] ...

experiment example 3

[0022] Experimental example three. The effect of Ganoderma lucidum extract on the drinking amount of sugar water in rats with chronic unpredictable stress The establishment of chronic unpredictable stress model and the experimental method are the same as above.

[0023] The reduction of sugar water consumption is an indicator of the degree of anhedonia in chronic unpredictable stress rats. During the 21-day chronic stress process, on the 1st, 8th, 15th, and 22nd days, after the daily stress, water and food were deprived, and sucrose water and ordinary water were given after 20 hours. After 1 hour, the rats were measured volume of drinking water. Because the amount of drinking water is positively correlated with body weight, it is more reliable to calculate the relative water drinking amount, that is, the ratio of drinking water amount to body weight for investigation. The results showed (see Table 3), on the 15th and 22nd day of chronic stress, the relative consumption of su...

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PUM

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Abstract

The present invention provides one kind of glossy ganoderma extract for preventing and treating depression and sleep disorder of different causes. The glossy ganoderma extract contains glossy ganoderma polysaccharides, nucleosides, furans, sterols, alkaloids, amino acids and tritrepenes, as well as inorganic ions, organogermanium, etc. It may be mixed with various kinds of depression resisting, tranquilizing and hypnotic medicine and excipient to prepare medicine and health product for preventing and treating depression and sleep disorder of different causes.

Description

technical field [0001] Depression is a common clinical mood disorder disease with a high incidence rate and seriously endangers the physical and mental health of patients. With the development of society, the pace of life is accelerated, and the competition for employment is intensified, the incidence rate will increase year by year. WHO estimates that there have been more than 300 million patients worldwide, and currently ranks fourth among diseases. It is predicted that by 2020 it may rise to No. 2. The suicidal tendency of depression is very serious, and the suicide rate is about 15%. The pathogenesis of depression is complex and the clinical symptoms are diverse. The main feature of a depressive state is a depressed mood. The specific manifestations are sadness, pessimism, and despair. Anhedonia is one of the common symptoms of depression patients. Somatic or biological symptoms are mainly manifested as biological symptoms such as loss of appetite, sleepy eye disorde...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61P25/24A61P25/20
Inventor 张永鹤陈宝琼褚青平林志彬
Owner PEKING UNIV
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