Methods for transmembrane treatment and prevention of otitismedia

A technology for the middle ear and tympanic membrane, applied in the field of transmembrane treatment and prevention of otitis media, which can solve pain, invasiveness and other problems

Inactive Publication Date: 2007-09-05
PIEDMONT PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is invasive and painful, indicating a strong need for other routes of introduction of antibiotics into the middle ear

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] This section provides examples of starting materials for the preparation of ciprofloxacin-containing transmembrane carrier compositions of the present invention. The transmembrane carrier composition included liposomes and contained the following ingredients with the listed w / w percentages.

Embodiment 2

Exemplary Process for Manufacturing Formulation A

[0045] This section provides an example of how to make a transmembrane carrier composition of the invention comprising ciprofloxacin.

[0046] water box. The method is preferably carried out with two jacketed stainless steel vortex hydration chambers. In the larger of the two compartments, slowly mix the pure water and benzethonium chloride to avoid the formation of foam or surface air bubbles. Heat was applied to reach a target temperature of 50°C ± 2°C for the aqueous phase. The chamber is covered to prevent water evaporation and is equipped with bottom ports and valves to regulate the flow of material out of the container.

[0047] fat phase. A second stainless steel jacketed mixing vessel was applied next to the first vessel. In this second chamber, first slowly mix the dehydrated alcohol and propylene glycol to avoid the formation of foam or surface air bubbles. Start the upper mixer and apply heat to reach 58±2°C, ...

Embodiment 3

Treatment of otitis media with an exemplary formulation

[0050] For the treatment of middle ear infections and their sequelae in infected individuals, the drug-containing liposomes according to the invention are administered to patients by transmembrane administration to the eardrum. Medications are those useful in the prevention and / or treatment of middle ear infections and are antibiotics, antivirals or pain relievers such as non-steroidal anti-inflammatory drugs.

[0051] Transmembrane administration is accomplished by, for example, applying a transmembrane carrier composition of the invention to the tympanic membrane with a needle-free syringe or other device suitable for medical insertion into the ear canal. Administration is repeated as necessary to obtain a therapeutically effective dosage level of the antibiotic compound administered. Pain can be treated in the same general manner by administering the transmembrane carrier compositions of the present invention contain...

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PUM

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Abstract

Methods for treating and preventing middle ear infections by transmembrane administration of medicament-containing transmembrane carrier compositions, such as liposomes and other lipid vesicles, to the tympanic membrane. Medicaments useful for treating pain, inflammation or infection in the outer ear may be co-administered. If utilized for transmembrane administration, the liposomes or other lipid vesicles will usually not be sterically stabilized. The medicaments delivered according to the methods of the invention include antibiotic, anti-viral, anti-fungal and anti-inflammatory agents that are useful in treatment and / or prophylaxis of middle ear infections and their sequelae.

Description

field of invention [0001] The present invention relates to a non-invasive method of treating otitis media (middle ear infection). More specifically, the present invention relates to a method of administering a drug for treating otitis media to the middle ear by administering the drug across the tympanic membrane (eardrum). Background technique [0002] Otitis media, ie, an infection of the middle ear, affects millions of children each year. While adults are also susceptible to middle ear infections, children are especially at risk because their relatively short ear canals are more accessible to inflammation. Fluid can then lodge behind the eardrum (tympanic membrane), which can cause severe pain, as well as provide a favorable environment for microorganisms to multiply in. [0003] The eardrum is an impenetrable barrier that prevents the introduction of drugs into the middle ear, so antibiotics prescribed to treat middle ear infections are almost always taken by mouth. Ho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/00
Inventor W·R·坎贝尔
Owner PIEDMONT PHARMA LLC
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