Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hypotensive portion of Hebei chrysanthemum extracts, extracting method and application in pharmaceutics thereof

A technology of effective part and chrysanthemum extract, which is applied to the extract of chrysanthemum antihypertensive effective part and its separation and extraction, and the application field of pharmaceutical preparations. It can solve the problems of separation and extraction that have not been reported yet, and achieve a stable effect

Inactive Publication Date: 2007-08-01
HEBEI MEDICAL UNIVERSITY
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the determination and separation of the effective parts of Hebei Fragrant Chrysanthemum for antihypertensive medicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hypotensive portion of Hebei chrysanthemum extracts, extracting method and application in pharmaceutics thereof
  • Hypotensive portion of Hebei chrysanthemum extracts, extracting method and application in pharmaceutics thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Preparation of the extract from the antihypertensive effective part of Hebei Fragrant Chrysanthemum

[0073] (1) Hebei Xiangchrysanthemum was extracted twice by reflux with 70% ethanol, the filtrates were combined and concentrated under reduced pressure to obtain a chrysanthemum extract, which was set aside.

[0074] (2) Resin pretreatment: D-101 type macroporous resin was soaked in 95% ethanol for 24 hours, rinsed with 95% ethanol until the ethanol was colorless and transparent, collected the last 50ml, evaporated to dryness, no white powdery matter. Rinse with 5% sodium hydroxide 2 times the volume of the resin bed, rinse with distilled water until neutral, then rinse with 5% HCl solution 2 times the volume of the resin bed, rinse with distilled water until neutral.

[0075] (3) According to the loading amount of chrysanthemum extract (converted to the amount of crude drug): resin=1:2~1:4, put the chrysanthemum extract on the column, control the flow rate of the efflu...

Embodiment 2

[0078] Preparation of Hebei Fragrant Chrysanthemum ≤ 60% Ethanol Eluted Extract

[0079] (1) Hebei Fragrant Chrysanthemum (purchased from Shijiazhuang Fragrant Chrysanthemum Technology Development Co., Ltd.) was refluxed twice with 70% ethanol, and the filtrates were combined and concentrated under reduced pressure to obtain a chrysanthemum extract, which was set aside.

[0080] (2) Resin pretreatment: HPD-600 macroporous resin was soaked in 90% ethanol for 24 hours, rinsed with 95% ethanol until the ethanol was colorless and transparent, collected the last 50ml, evaporated to dryness, no white powdery matter. Rinse with 5% sodium hydroxide 2 times the volume of the resin bed, rinse with distilled water until neutral, then rinse with 5% HCl solution 2 times the volume of the resin bed, rinse with distilled water until neutral.

[0081] (3) According to the loading amount of chrysanthemum extract (converted to the amount of crude drug): resin = 1:3, put the chrysanthemum extrac...

Embodiment 3

[0084] Antihypertensive Tablets Prepared by Hebei Fragrant Chrysanthemum Antihypertensive Effective Fraction Extract as Active Ingredient

[0085] 2000 kg of ≤ 40% ethanol eluted extract prepared by the method of Example 1, according to the conventional tablet preparation method, add starch, dextrin, magnesium stearate, etc., mix to make wet granules, and machine stamped into tablets, each tablet Contains 10mg of total flavonoids.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the depressurization active part extracts of Hebei chrysanthemum, the preparing method and its application in the medical preparation is also mentioned in the invention. The extract is obtained through adsorbing the extracted solution by macroporous resin and eluting by alcohol (less than 60%). The preparing procedure includes the following steps: getting the extracted solution from Hebei chrysanthemum with routine method; adsorbing and eluting the solution, the eluting solution is alcohol (the density of which is smaller than 60%); collecting the eluted solution; condensing and drying. The extract can be used as the active ingredient to prepare different kinds of pharmaceutical dosage forms such as soft capsule, pellet, dripping pills, injectable preparation and slowly controlled releasing dosage. The invention has provided a new and steady hypotensive drug for clinical use.

Description

technical field [0001] The present invention relates to medicinal active ingredients of plants and its extraction and preparation method and application, in particular to the extract of chrysanthemum antihypertensive effective parts, its separation and extraction method and its application in pharmaceutical preparations. Background technique [0002] Chrysanthemum (Chrysanthemum morifolium Ramat.) is the inflorescence head of Chrysanthemum chrysanthemum, which has the functions of dispelling wind, clearing heat, improving eyesight and detoxifying. Clinically, it is mainly used to treat headache, dizziness, red eyes, dysphoria in the heart and chest, boils, and swelling. Studies have shown that chrysanthemum contains multiple medicinal active ingredients, and it is generally believed that flavonoids, triterpenoids, and volatile oil are its main active ingredients. Pharmacological experiments show that the total extract of chrysanthemum has a positive effect on the prevention...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P9/12A61K133/00
Inventor 赵丁黄芸张霞任雷鸣李贵娟
Owner HEBEI MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com