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Remote controlled modicine reliesing electronic capsule capable of partly degradation

An electronic capsule and drug release technology, which is applied in the fields of capsule delivery, drug delivery, and pharmaceutical formulations, can solve problems such as large clinical use risks, and achieve the effects of improving clinical safety, easy mass production, and good practicability

Inactive Publication Date: 2007-07-18
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the problem with the current technical solution is that the shape of the electronic capsule remains unchanged during the process of passing through the entire digestive tract, and the fact that the electronic capsule can be swallowed does not mean that the capsule can be smoothly discharged. If there is an obstruction somewhere in the tract, the electronic capsule can only be removed by surgery, or even by laparotomy. Therefore, the current technical solution has a greater risk of clinical use.

Method used

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  • Remote controlled modicine reliesing electronic capsule capable of partly degradation
  • Remote controlled modicine reliesing electronic capsule capable of partly degradation
  • Remote controlled modicine reliesing electronic capsule capable of partly degradation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] This embodiment provides a partially degradable electronic capsule for remote drug release, which includes a capsule shell 1, a driving mechanism, a drug tablet core 2, and a drug release channel mechanism. The drug release channel mechanism includes a drug release through hole 4 and a sealing plug 5. One end of the drug tablet core 2 includes a protruding mechanism 3, which can open the drug release channel mechanism under the action of a driving force. The capsule shell 1 includes a shell support 6, a shell coating 7, and the shell support 6 can be inserted into the digestive tract. The liquid dissolves or decomposes, and the shell coating 7 is made of a material that cannot be dissolved or decomposed by the liquid of the digestive tract, and is evenly coated on the outside of the shell support 6 . In this embodiment, the material of the shell coating is medical grade paraffin, and the thickness of the shell coating is 0.3 mm.

[0030] The driving mechanism includes a...

Embodiment 2

[0041]A partially degradable electronic capsule for remote drug release includes a capsule shell 1, a driving mechanism, a drug tablet core 2, and a drug release channel mechanism. The drug release channel mechanism includes a drug release through hole 4 and a sealing plug 5. One end of the drug tablet core 2 includes a protruding mechanism 3, which can open the drug release channel mechanism under the action of a driving force. The capsule shell 1 includes a shell support 6, a shell coating 7, and the shell support 6 can be inserted into the digestive tract. The liquid dissolves or decomposes, and the shell coating 7 is made of a material that cannot be dissolved or decomposed by the liquid of the digestive tract, and is evenly coated on the outside of the shell support 6 . In this embodiment, the material of the shell coating is medical-grade paraffin, and the thickness of the shell coating is 0.25 mm.

[0042] The driving mechanism includes a driving mechanism housing 8 and...

Embodiment 3

[0049] A partially degradable electronic capsule for remote drug release includes a capsule shell 1, a driving mechanism, a drug tablet core 2, and a drug release channel mechanism. The drug release channel mechanism includes a drug release through hole 4 and a sealing plug 5. One end of the drug tablet core 2 includes a protruding mechanism 3, which can open the drug release channel mechanism under the action of a driving force. The capsule shell 1 includes a shell support 6, a shell coating 7, and the shell support 6 can be inserted into the digestive tract. The liquid dissolves or decomposes, and the shell coating 7 is made of a material that cannot be dissolved or decomposed by the liquid of the digestive tract, and is evenly coated on the outside of the shell support 6 . In this embodiment, the material of the shell coating is medical-grade paraffin, and the thickness of the shell coating is 0.4 mm.

[0050] The driving mechanism comprises a driving mechanism housing 8 an...

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Abstract

A remotely controlled slow-releasing electronic capsule able to be partially degradated for releasing medicine, food or making substance in digestive tract is composed of casing, remotely controlled driver, slow-releasing channel of medicine and a medicine tablet core with a conic or cylindrical boss at its one end. Under the drive of said driver, said boss on medicine tablet can move forward to open the medicine releasing channel for slowly releasing the medicine. Said casing consists of the scaffold able to be degradated and a coated layer.

Description

Technical field: [0001] The invention relates to a partially degradable electronic capsule for remote drug release, in particular to a device for releasing drugs into the digestive tract, which is used for remotely releasing substances, such as drugs, food, markers, etc., in the digestive tract of animals or humans. Background technique: [0002] Drug-release electronic capsule is a drug release system based on micro-mechanical electronic technology. It can control the release time and location of drugs in the digestive tract through remote control outside the body. It has good application value in clinical treatment and drug absorption research in the digestive tract. In Chinese patents CN200410040809.3 and ZL02128141.6, the schemes of drug-releasing electronic capsules are disclosed. The shells of current drug-releasing electronic capsules are generally made of materials such as plastics or stainless steel with good biocompatibility, and their common characteristics are go...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00A61D7/00A61B5/06A61K9/48A61K9/52
CPCA61M31/002
Inventor 皮喜田杨军刘洪英周承文郑小林彭承琳赵素文林玉琳
Owner CHONGQING UNIV
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