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Grafted nano carbon mixed suspension and its preparing process

A technology of grafting nano-carbon and suspension, applied in the field of medicine

Active Publication Date: 2009-05-06
SICHUAN YINGRUI PHARMA TECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, grafted nano-carbons have not been used in lymphatic tracing and lymphatic targeted therapy in the medical field.

Method used

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  • Grafted nano carbon mixed suspension and its preparing process
  • Grafted nano carbon mixed suspension and its preparing process
  • Grafted nano carbon mixed suspension and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Purification and preparation of nano-carbon

[0028] Using the method disclosed in the Chinese invention patent "A Preparation Method of Nano-carbon Suspension Composition", using No. 40 carbon black as the chemical raw material, degreasing with ethyl acetate, washing with acid and alkali to reduce ash and heavy metals, and then washing with a large amount of water to remove acid , alkali, and make purified nano-carbon as raw material for preparing grafted nano-carbon. Nano carbon purification preparation process steps are as follows:

[0029] 1. Ethyl acetate degreasing

[0030] Weigh 1600g of No. 40 carbon black and place it in an appropriate container, add 6000ml of ethyl acetate. Heated to reflux for 1 hour, filtered, and the filter residue was treated once more, and dried in vacuum for 2 hours to obtain 1420.59 g of crude product with a yield of 89.12%. The light transmittance of the toluene extract was 99.98%.

[0031] 2. Acid washing, alkali washing ...

Embodiment 2

[0037] Example 2 Preparation of grafted nano-carbon

[0038] 1. Oxidative grafting reaction of nano-carbon:

[0039]Put 499.35 g of nano-carbon purified by carbon black into an acid-resistant container, add 20000 ml of 67% concentrated nitric acid, heat to 100 ° C, and reflux at this temperature for 100 hours.

[0040] 2. Separation and extraction of grafted nano-carbon:

[0041] After the temperature of the carbon black nitric acid solution after the reaction drops to normal temperature, centrifuge at 5600rpm for 30 minutes, move the upper black liquid into a suitable container, and evaporate under reduced pressure at a temperature of 70°C to obtain a dark brown black solid; Continue to add distilled water to the black precipitate, stir for 2 hours, and centrifuge at 5600rpm for 30 minutes. After centrifugation, the upper liquid is black, and the black precipitate is significantly reduced; move the upper black liquid into a suitable container, and evaporate under reduced pre...

Embodiment 3

[0079] Example 3 Preparation Method 1 of Grafted Nano-carbon Suspension

[0080] First, weigh 50 grams of grafted nano-carbon and put it in a glass container with a capacity of 2000ml, add 300ml of normal saline, stir for 60 minutes at room temperature, then add 300ml of normal saline, stir for 60 minutes, continue to add normal saline to 1000ml, use 10% Sodium hydroxide adjusted the pH to 6.9.

[0081] Filter the suspension with a pH value of 6.9 above through a 0.22 μm microporous membrane, either under pressure on the input side of the membrane or under negative pressure on the output side of the membrane, to remove large particles and bacteria.

[0082] Packing: 1ml / bottle. Plugging, pressing aluminum caps, leak detection, quality inspection, packaging.

[0083] The prepared grafted nano-carbon suspension has a dark brown-black color, an average particle diameter of 84nm (FIG. 7), a pH value of 6.9, and is sterile.

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Abstract

The present invention discloses one kind of grafted nanometer carbon suspension consisting of grafted nanometer carbon grain, physiological saline and pH regulator and its preparation process. The grafted nanometer carbon suspension may be used as lymph tracing medicine, which is injected in body of human or animal to enter the draining lymph node fast and to dye the lymph node into black or grey. The grafted nanometer carbon suspension may be also used as lymph targeting medicine, which is injected into the malignant tumor to reach the draining lymph node fast in the malignant tumor and to kill the metastic cancer cell inside lymph node directly.

Description

technical field [0001] The invention relates to a grafted nano-carbon suspension and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Chinese invention patent "Preparation Method of Nano-carbon Suspension Composition" (application number: 02113731.5, has obtained the "Notice of Granting Invention Patent Right") discloses a nano-carbon for tracing regional draining lymph nodes of malignant tumors Method of preparation of the suspension. The characteristics of this technology are: due to the hydrophobic nature of the nano-carbon surface structure, it cannot be directly dispersed in an aqueous solution to form a nano-carbon suspension. A nanocarbon suspension is formed. After the nano-carbon suspension is injected into the local tissue, it can selectively enter the drainage lymph nodes of the local tissue, stain these lymph nodes black, and help doctors identify lymph nodes with the naked eye, achieve the effect of lymphatic trac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/10A61K33/44C01B31/08A61K47/02A61K47/30A61P35/00
Inventor 唐小海
Owner SICHUAN YINGRUI PHARMA TECH CO
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