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Tiny-wound, dynamic and continuous detecting method and system of concentration of sugar in human blood

A technology of blood sugar concentration and detection system, which is applied in the field of human blood glucose concentration detection system, can solve the problems of limited detection accuracy of non-invasive detection method, great influence of skin surface environmental conditions, difficult operation, etc., and achieve good clinical application prospects, tissue fluid volume to be measured The effect of small size, high measurement resolution and high measurement accuracy

Active Publication Date: 2009-04-29
TIANJIN SUNRISE TECH DEV
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Problems solved by technology

These methods have been unable to achieve clinical application due to the disadvantages of complex devices, difficult operation, easy infection, and great influence on the skin surface environment.
Due to the shortcomings of limited detection accuracy and low reliability of non-invasive detection methods, clinical application has not been realized, and it is still in the research stage

Method used

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  • Tiny-wound, dynamic and continuous detecting method and system of concentration of sugar in human blood
  • Tiny-wound, dynamic and continuous detecting method and system of concentration of sugar in human blood
  • Tiny-wound, dynamic and continuous detecting method and system of concentration of sugar in human blood

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Embodiment Construction

[0056] The present invention first uses low-frequency ultrasound to pretreat the skin, destroys the lipid bilayer structure in the stratum corneum of the skin through the cavitation of the low-frequency ultrasound, increases the permeability of the skin, and then uses the method of vacuum negative pressure to remove the lipid from the skin rapidly. The tissue fluid is extracted, and finally the extracted tissue fluid is transported to the surface plasmon resonance measurement system through a microchannel, and the surface plasmon resonance refractive index direct measurement technology or protein binding indirect measurement technology is used to measure the glucose concentration in the human tissue fluid. According to the glucose concentration in the tissue fluid The correlation prediction model between the concentration and the glucose concentration in the blood realizes the dynamic, continuous and real-time detection of the blood glucose concentration in the human body. figu...

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Abstract

The present invention proposes method and system for detecting human body blood sugar concentration dynamically and continuously in microtrauma. The detection method includes the first low frequency ultrasonic treatment of skin to increase permeability of skin, the subsequent negative pressure microtraumatic extraction of tissue fluid from skin and conveying the extracted tissue fluid through micro passage to a surface plasma resonance sensor system, measuring the glucose concentration in the tissue fluid through direct measurement of surface plasma resonance refractivity or indirect measurement of protein binding, and final dynamic continuous detection of blood sugar concentration according to the correlativity model between the glucose concentration in blood and the glucose concentration in tissue fluid. The corresponding detection system is also provided. The present invention has excellent clinical application value.

Description

technical field [0001] The invention relates to a human body blood sugar concentration detection system adopting the method, and belongs to the technical field of human body physiological parameter detection. Background technique [0002] Diabetes is a common and frequently-occurring disease among middle-aged and elderly people. With the improvement of people's living standards, the incidence of diabetes is also increasing. The World Health Organization lists it as one of the three most difficult diseases in the world together with tumors and cardiovascular and cerebrovascular diseases. According to the estimates of the World Health Organization, there are about 170 million diabetics in the world and about 30 million diabetics in China. It will increase to 300 million people by 2025. Diabetes has long been listed as one of the top ten killers in Asia, and its prevalence has surpassed the threat of infectious diseases. Active prevention and treatment of diabetes is imminent....

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/145G01N33/66
Inventor 徐可欣栗大超黄显于海霞张增幅
Owner TIANJIN SUNRISE TECH DEV
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