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Eye drops with capillary artemisia, cape jasmine and baikal skullcap root, and its preparing method

An eye drop, the technology of Yinzhihuang, applied in the field of Yinzhihuang pharmaceutical preparations, can solve the problems of loss of health and work and life, increase of drug-resistant strains, increase of adverse reactions, etc., and achieve good clarity and high absorption and utilization , excellent therapeutic effect

Inactive Publication Date: 2008-09-10
SINOPHARM A THINK PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Once an epidemic breaks out, it often brings serious losses to people's health and work life
[0003] The treatment of conjunctivitis is mostly treated with chemical drugs such as antibiotics and antivirals. There is a common problem of overuse of antibiotics in clinical practice, which has led to the continuous increase of drug-resistant strains and the side effects of increased adverse reactions.
Most of the previous first-line drugs for bacterial conjunctivitis, such as chloramphenicol and rifampicin, are resistant to drugs; the incidence of chronic conjunctivitis ranks first in various ophthalmic diseases, and there is no specific drug treatment at present; viral acute hemorrhage Antibiotics for conjunctivitis are generally ineffective, while antiviral eye drops have a certain effect, but like antibiotics, they all have different degrees of drug resistance and adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Capillary wormwood extract Capillary wormwood was taken, and 15 times the amount of 90% ethanol was used as a solvent to percolate according to the percolation method. Combine the percolation liquid, remove oils such as chlorophyll, and filter with a hollow fiber membrane with a molecular weight cut-off of 30,000 aperture. The filtrate was concentrated to a relative density of 1:1.30 (70°C), and the extract was obtained by drying under reduced pressure.

Embodiment 2

[0022] Gardenia extract Gardenia was taken, and 8 times the amount of 70% ethanol was added to reflux for extraction three times, each time for 40 minutes, and the reflux liquid was combined and filtered through a hollow fiber membrane with a molecular weight cut-off of 30,000 pores. The filtrate was concentrated to a relative density of 1:1.30 (70°C), and the extract was obtained by drying under reduced pressure.

Embodiment 3

[0024] Preparation of Scutellaria baicalensis extract Scutellaria baicalensis was decocted with water twice, each time for 1 hour, filtered, combined with the filtrate, adjusted to pH 1.0-2.0 with hydrochloric acid, kept at 80°C, left standing, baicalin coagulated and precipitated, and filtered. Discard the filtrate, add an appropriate amount of water to the precipitate, stir well, adjust the pH value to 7.0 with 40% sodium hydroxide solution, add an equal amount of ethanol, stir to dissolve, and filter. The filtrate was adjusted to a pH value of 1.0-2.0 with hydrochloric acid, heated to 60°C, allowed to stand still to precipitate baicalin, and filtered. The precipitate was successively washed with appropriate amount of water and different concentrations of ethanol until the pH value reached 7.0, evaporated the ethanol, and dried under reduced pressure to obtain the final product. This product contains baicalin should not be less than 85.0%.

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PUM

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Abstract

The present invention relates to a kind of Yizhihuang eye drops and its preparation method. It can be used for curing the diseases of conjunctivitis, bacterial conjunctivitis, viral conjunctivitis, acute hemorrhagic conjunctivitis, neonatal bacterial conjunctivitis and chronic conjunctivitis and keratitis, etc. It is made up by using four Chinese medicinal materials of lonicera flower, scutellaria root, capillaries and gardenia fruit through a certain preparation process.

Description

technical field [0001] The present invention relates to a Yinzhihuang pharmaceutical preparation, in particular to Yinzhihuang eye drops, which can be used to treat conjunctivitis, bacterial conjunctivitis, viral conjunctivitis, acute hemorrhagic conjunctivitis, and neonatal bacterial conjunctivitis inflammation and chronic conjunctivitis Background technique [0002] Conjunctivitis is a common and frequently-occurring disease in ophthalmology, including bacterial, viral, clothing and immune-related conjunctivitis. Among them, acute hemorrhagic conjunctivitis is caused by viral infection. It has an acute onset and is highly contagious. The incidence rate is as high as 7.45%. bit. Once an epidemic breaks out, it often brings serious losses to people's health and work life. [0003] The treatment of conjunctivitis is mostly treated with chemical drugs such as antibiotics and antivirals. There is a common problem of overuse of antibiotics clinically, which leads to the conti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744A61K9/08A61P27/02
Inventor 王振国贾志丹刘贺之周颖苏彦珍王涛吴素林
Owner SINOPHARM A THINK PHARMA
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