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Method for preparing rhubarb sulfur gel agent

A yellow gel, rhubarb technology, applied in the field of preparation of rhubarb sulfur gel, can solve problems such as inconvenience in use, and achieve the effects of easy cleaning, stable properties and convenient use

Inactive Publication Date: 2008-08-13
JIANGSU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the disadvantages of inconvenient use of the traditional dosage form of Tiaoduosan, the present invention combines the pharmacological activity of the above-mentioned drugs, uses free anthraquinone and sulfur from rhubarb extract as the main drug, uses carbomer as the gel matrix, and uses propylene glycol and urea as the mixed penetrating agent. Skin accelerator, prepare rhubarb sulfur gel, and provide a traditional Chinese medicine compound external preparation for treating acne for clinical use. The preparation has the characteristics of convenient use, less dosage, safety, reliability and good curative effect

Method used

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  • Method for preparing rhubarb sulfur gel agent
  • Method for preparing rhubarb sulfur gel agent
  • Method for preparing rhubarb sulfur gel agent

Examples

Experimental program
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Effect test

example 1

[0014] The preparation method of example 1 rhubarb sulfur gel

[0015] A prescription:

[0016] Rhubarb 37.0g Precipitated sulfur 30.0g Glycerin 20.0g

[0017] Propylene Glycol 100.0g Urea 50.0g Carbomer-940 7.0g

[0018] Add 5.5g of triethanolamine to 1000g of water

[0019] B preparation process:

[0020] Weigh 37.0g of rhubarb coarse powder, add 370mL of 40% ethanol to extract once, extract for 1h, filter, concentrate the filtrate until there is no alcohol smell, and obtain the extract concentrate, add 1 / 30 concentrated hydrochloric acid of the volume of the concentrate, and place in a water bath at 80°C Heat for 1 hour to obtain a hydrolyzate, add 3 times the volume of the hydrolyzate to dilute with water, then adjust the pH to 9 with 40% sodium hydroxide, centrifuge, discard the precipitate, take the supernatant, put it on a pretreated D392 resin column, and use Rinse with deionized water until it is colorless, elute with an eluent whose NaOH concentration is 0.1mol / L...

example 2

[0022] The preparation method of example 2 rhubarb sulfur gel

[0023] A prescription:

[0024] Rhubarb 81.5g Precipitated sulfur 50.0g Glycerin 50.0g

[0025] Propylene Glycol 200.0g Urea 100.0g Carbomer-940 10.0g

[0026] Triethanolamine 7.7g water to 1000g

[0027] B preparation process:

[0028] Weigh 82.5g of rhubarb coarse powder, add 2460mL of 50% ethanol to extract 3 times, extract for 1 hour every time, filter, concentrate the filtrate until it has no alcohol smell, and obtain the extraction concentrate, add 1 / 20 concentrated hydrochloric acid of the volume of the concentrate, and heat at 80°C Heat in a water bath for 1 hour to obtain a hydrolyzate, add 4 times the volume of the hydrolyzate to dilute with water, then adjust the pH to 9 with 40% sodium hydroxide, centrifuge, discard the precipitate, take the supernatant, and put it on a pretreated D392 resin column, Rinse with deionized water until it is colorless, elute with an eluent with a NaOH concentration of ...

example 3

[0030] The preparation method of example 3 rhubarb sulfur gel

[0031] A prescription:

[0032] Rhubarb 148.1g Precipitated sulfur 100.0g Glycerin 100.0g

[0033] Propylene Glycol 200.0g Urea 150.0g Carbomer-940 20.0g

[0034] Triethanolamine 9.6g water added to 1000g

[0035] B preparation process:

[0036] Weigh 148.1 g of rhubarb coarse powder, add 2960 mL of 50% ethanol to extract twice, extract for 1 hour each time, filter, concentrate the filtrate until it has no alcohol smell, and obtain the extract concentrate, add 1 / 20 concentrated hydrochloric acid of the volume of the concentrate, 80 Heat in a water bath at ℃ for 1 hour to obtain a hydrolyzate, add 5 times the volume of the hydrolyzate to dilute with water, then adjust the pH to 9 with 40% sodium hydroxide, centrifuge, discard the precipitate, take the supernatant, and put it on the pretreated D392 resin column , rinsed with deionized water until colorless, eluted with an eluent whose NaOH concentration was 0.2m...

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Abstract

The invention relates to the process for preparing gelling agent of rhubarb horsetails and sulfur by using free anthraquinone of rhubarb horsetails extract and sulfur as the main constituents, using carbomer as the gel matrix, and using methyl ethylene glycol and urea as the mixed transdermal accelerating agent. The preparation can be used for treating acne.

Description

technical field [0001] The invention relates to a preparation method of rhubarb sulfur gel, which belongs to the field of traditional Chinese medicine preparation. Background technique [0002] Acne is an inflammatory disease of the skin adnexa. The skin lesions mainly involve the face and upper trunk, covering a wide area. At present, this disease accounts for a relatively high proportion of dermatology visits, and it has an increasing trend. It has attracted the attention of clinical dermatologists and experts. . It is generally believed that the occurrence of acne is related to factors such as microbial factors and inflammatory reactions. [0003] At present, macrolides, tetracyclines and lincomycins are mainly used clinically to treat acne, but the phenomenon of antibiotic resistance is becoming more and more serious. Studies have reported that the incidence of drug-resistant bacteria in acne patients is increasing year by year, among which erythromycin is the most com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K36/704A61K33/04A61P17/10
Inventor 陈钧陈红斌
Owner JIANGSU UNIV
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