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Method for preparing carbonized resin DNA immunoadsorbent

A technology of immunoadsorbent and resin, which is applied in the parts of color TV, TV system, structural parts of portable computer, etc. It can solve the problems that the coating conditions need to be improved, the price is expensive, etc., and the damage rate is low, Good blood compatibility, low cost effect

Inactive Publication Date: 2007-11-14
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical application, it is found that the patients have shivering phenomenon, which indicates that there are pyrogen substances in the adsorbent.
In addition, the coating conditions need to be improved to improve the adsorption performance of the adsorbent
In addition, the current carbonized resin is expensive, and it is necessary to improve the manufacturing process of carbonized resin in order to reduce the cost and promote the clinical application of immunosorbents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Prepare charred resin.

[0031]Mix 45.0g styrene, 60.0g divinylbenzene, 45.0g acrylonitrile, and 300.0g toluene evenly, add 1.5g initiator benzoyl peroxide, dissolve and add 160.0g liquid paraffin, and mix well. In a 3000mL three-neck flask, add 1150mL of 1% polyvinyl alcohol aqueous solution, heat to 50°C in a water bath, pour the above monomer solution into the reaction flask, stir, and raise the temperature of the reaction solution to 80°C within 1 hour, and react for 5 hours. Raise the temperature of the water bath to above 90°C and distill the toluene for about 1 hour until no more toluene is distilled out. Boil the spherical polymer at 100°C for 2 hours to further polymerize and harden, filter and wash with hot distilled water several times to remove polyvinyl alcohol. Dry at 50°C, rinse the resin with petroleum ether (60-90°C), and remove the liquid paraffin in the porogen. Use a standard sieve to screen qualified resin in the range of 0.45-1.0mm, about 400mL. ...

Embodiment 2

[0038] In this example, in the process of preparing the carbonized resin in Example 1, the temperature of the carbonized resin in the tubular resistance furnace was changed to 580°C. As a result, the specific surface area of ​​the obtained carbonized resin was only 100m 2 / g or so. All the other steps are the same as in Example 1. From the change of this parameter, it can be seen that the DNA content in the finished adsorbent will be greatly reduced.

Embodiment 3

[0040] In the process of preparing the carbonized resin in Example 1, the water vapor activation time in the process of preparing the carbonized resin was changed to 0.5 hours. As a result, the specific surface area of ​​the obtained carbonized resin was slightly reduced, which was 800-1000m 2 / g. All the other steps are the same as in Example 1. It can be deduced from this that the DNA content in the finished adsorbent will also be reduced accordingly.

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PUM

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Abstract

The invention provides a method for preparing carbonized resin DNA immunoadsorbent, in which the resin DNA immunoadsorbent having DNA of 0.3-0.5 mg / ml can be produced, taking styrene, acrylonitrile, divinylbenzene, toluene, white oil, benzoyl peroxide, and polyvinylalcohol auqeous solution as raw materials, by both phases of preparing carbonized resin and preparing carbonized resin DNA immunoadsorbent. The immunoadsorbent is better suitable to the clinical requirement on clinic, having high adsorbent ability and no heat source matter, as well as low manufacturing cost. The immunoadsorbent is popularized to treat systemic lupus erythematosus.

Description

technical field [0001] The invention relates to a medical adsorption material, in particular to an immunoadsorbent. The adsorbent immobilizes the active substance DNA on the carbonized resin as the carrier material to become a DNA immunoadsorbent, which can be used for hemoperfusion therapy for treating systemic lupus erythematosus. Background technique [0002] Systemic lupus erythematosus (SLE for short) is an intractable disease of autoimmune deficiency, and there is no effective therapy in clinical practice. The etiology of SLE is unknown, and patients often die due to the failure of vital organs throughout the body, with a high mortality rate. [0003] Hemoperfusion of patients with DNA immunoadsorbent is a new type of therapy developed in the past ten years. The European patent EP0272792A1 (1987) of Janes Frank R has described this method in detail, and the whole content of this patent document is taken as the reference of this application. DNA immunoadsorbent hemop...

Claims

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Application Information

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IPC IPC(8): A61K39/44G01N33/545G01N33/564A61P37/00H04N5/225G02B27/01G06F1/16H04N5/232H04N7/18
CPCG06F1/163G02B27/017H04N5/232A61P37/00
Inventor 俞耀庭陈长治孔德领
Owner JAFRON BIOMEDICAL
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