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Peptide

a technology of peptides and peptides, applied in the field of glp1 (737), can solve the problems of high risk of diabetic complications, poor treatment effect, and insatiable patients, and achieve the effect of improving the ability of patients to respond to treatment, and improving the effect of treatment

Inactive Publication Date: 2001-07-31
NOVO NORDISK AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to the surprising finding that when GLP-1 related peptides are administered in combination with oral hypoglycaemic agents in general and with sulfonylureas in particular for treatment of type 2 diabetes, a synergistic effect is observed. This surprising observation has been made even in type 2 diabetic patients who fail to respond when sulfonylureas are administered alone.

Problems solved by technology

Even though sulfonylureas are widely used in the treatment of NIDDM this therapy is, in most instances, not satisfactory: In a large number of NIDDM patients sulfonylureas do not suffice to normalize blood sugar levels and the patients are, therefore, at high risk for acquiring diabetic complications.
Also, many patients gradually lose the ability to respond to treatment with sulfonylureas and are thus gradually forced into insulin treatment.

Method used

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  • Peptide

Examples

Experimental program
Comparison scheme
Effect test

example 1

Synergistic Effect of GLP-1(7-36)amide and Glibenclamide in NIDDM Patients

Assays

Blood samples were collected in plastic tubes containing EDTA (0.048 ml, 0.34M) and Trasylol.RTM. (1000 IU Kallikrein inhibitor, obtained from Bayer, West Germany) and immediately placed on ice. The samples were centrifuged at 4.degree. C. and the plasma was stored at -20.degree. C. Blood glucose was measured by a glucose oxidase method according to A. S. Hugget and D. A. Nixon, Lancet 2 (1957) 368-370. Plasma C-peptide concentrations were determined by radioimmunoassay (RIA) using a commercially available kit. (Novo Research Institute, Denmark). Plasma glucagon concentrations were measured by RIA using antibody 30K as described by G. R. Faloona and R. H. Unger in B. M. Jaffe and Behrman, eds. Methods of Hormone Radioimmunoassay, Academic Press, New York (1974) 317-330.

For further experimental details (e.g. on calculation of isoglycaemic meal-related insulin response, IMIR), reference is made to M. Gutni...

example 2

Synergistic Effect of GLP-1(7-36)amide and Glibenclamide in NIDDM Patients with Secondary Failure to Sulfonylurea Treatment

Methods

Eight patients with NIDDM and secondary failure to sulfonylurea treatment participated in the study (age 57.6.+-.2.7 years, body mass index 28.7.+-.1.5 kg / m.sup.2, diabetes duration 7.6.+-.1.2 years, HbA.sub.1c 5.8.+-.0.5). The diabetic patients fulfilled the criteria for NIDDM and IDDM according to the USA National Diabetes Data Group. None of the patients had impaired renal function, automatic neuropathy, or proliferative retinopathy, and all had normal liver function. They were instructed to eat a standard diet for diabetic patients at least 2 weeks before and during the study. The patients treated with sulfonylureas stopped their medication one week before the experiments. Those who were treated with insulin were instructed to stop the injections of NPH insulin 24 hours before the studies. Blood glucose concentrations were controlled with subcutaneous...

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Abstract

The invention employs GLP-1(7-37), GLP-1(7-36)amide, and certain related compounds in combination with an oral hypoglycaemic agent for treating diabetes mellitus.

Description

FIELD OF THE INVENTIONThe present invention relates to the use of GLP-1(7-37), GLP-1(7-36)amide, or certain related compounds for the preparation of a medicament for use in the treatment of diabetes in a regimen which additionally comprises treatment with an oral hypoglycaemic agent. The invention also relates to a method of treating diabetes by using said medicament.BACKGROUND OF THE INVENTIONDiabetes is characterized by an impaired glucose metabolism manifesting itself among other things by an elevated blood glucose level in the diabetic patients. Underlying defects lead to a classification of diabetes into two major groups: type 1 diabetes, or insulin demanding diabetes mellitus (IDDM), which arises when patients lack .beta.-cells producing insulin in their pancreatic glands, and type 2 diabetes, or non-insulin dependent diabetes mellitus (NIDDM), which occurs in patients with an impaired .beta.-cell function besides a range of other abnormalities.Type 1 diabetic patients are cur...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K38/26
CPCA61K38/26A61K2300/00
Inventor EFENDIC, SUADGUTNIAK, MARKKIRK, OLE
Owner NOVO NORDISK AS
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