Methods for the treatment of inflammatory joint disease

Abstract

This invention provides compositions and methods for preventing inflammatory diseases of the joints, including rheumatoid and osteoarthritis, tendonitis, bursitis, inflammation of the ligament, synovitis, gout, and systemic lupus erythematosus, wherein the methods include injecting into the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral IL-10 expression construct, wherein the IL-10 expression construct comprises a bacterial or viral backbone and a nucleic acid sequence encoding interleukin-10.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of and claims priority under 35 U.S.C. § 120 to U.S. patent applications, U.S. Ser. No. 14 / 905,915, filed Jan. 18, 2016, which is a national stage filing under 35 U.S.C. § 371 of international PCT application, PCT / US2014 / 047071, filed Jul. 17, 2014, which claims the benefit of U.S. Provisional Patent Application No. 61 / 847,851, filed Jul. 18, 2013, each of which is incorporated herein by reference.STATEMENT REGARDING FEDERALLY FUNDED RESEARCH[0002]This invention was made with government support under grant number U44-NS071642 awarded by the National Institute of Health. The government has certain rights in the invention.FIELD OF THE INVENTION[0003]This invention relates to treating clinical conditions associated with inflammatory diseases of the joints and symptoms associated therewith by administering to the inflamed joint a therapeutic anti-inflammatory composition comprising a bacterial or viral inter...

AI Technical Summary

Benefits of technology

The present invention provides methods for treating inflammatory diseases of the joints by administering a therapeutic anti-inflammatory IL-10 compound to a subject. The IL-10 compound can be administered as a vector expressing an IL-10 coding sequence encapsulated in biodegradable microparticles or as a naked DNA with or without adjuvants. The therapeutic effect is to provide a therapeutically effective dose of IL-10 to the joint, which can slow down the progression of the inflammatory disease and reduce symptoms associated with it. The IL-10 compound can be administered with one or more adjuvants to increase uptake or efficacy of the IL-10 expression construct. The invention also provides methods for pre-treating a subject with an IL-10 expression construct and adjuvants to prevent or treat inflammatory diseases of the joints.

Problems solved by technology

When injured, a chain of events in the immune system known as the inflammatory cascade is triggered, causing redness, swelling and pain.

However, if inflammation persists it can lead to a more chronic condition.

Identifying treatments that would require less frequent administration would impact significantly the quality of life for patients with inflammatory joint disease; however, despite substantial research into and development of therapies for such conditions there is still a large unmet need for safe, effective, and easy-to-administer treatments.

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