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Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products

a technology of antimicrobial and antibiofilm composition, which is applied in the direction of biocides, othalmoscopes, dental prosthetics, etc., can solve the problems of eye infection, limitation, to some extent, the type and concentration of both cleaning agents, and the inability of microorganisms to adhere to contact lenses, etc., to achieve the effect of enhancing the stability and efficacy of anti-infective compounds

Active Publication Date: 2019-03-14
KANE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0013]Still another embodiment of the invention may provide an anti-infective composition comprising two chelating agents and one or two metal ion salts that are effective against bacteria and fungi causing infections through the personal care products.
[0024]The invention may also teach the use of liposomal or nanoparticle delivery systems that enhance the stability and efficacy of anti-infective compounds in the compositions.

Problems solved by technology

During wear and normal handling of contact lenses, microorganisms can adhere to the contact lenses and contaminate the storage containers / solution.
Then, microorganisms that multiplied in the storage containers / solution can transfer to the eyes via contact lenses and become a pathogen that may cause eye infection.
This limits, to some extent, the type and concentration of both cleaning agents, biocides, antibacterials, and antibiofilm agents that can be employed in the solution as a preservative or disinfectant as these tend to be irritating to the eye.

Method used

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  • Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products
  • Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products
  • Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products

Examples

Experimental program
Comparison scheme
Effect test

example 1

y Effect of Sodium Citrate, EDTA and Zinc Chloride Alone and in Combination on Methicillin-Resistant Staphylococcus aureus (MRSA) Growth and Biofilm Formation

[0089]An overnight broth culture of S. aureus was grown in TSB and used as inoculum. 96-well microplates containing TSB in the absence and the presence of each compound (sodium citrate or EDTA or Zinc chloride) separately and together (Sodium chloride+EDTA+Zinc chloride) were inoculated and incubated at 37° C. for 24 hours. Growth of plaktonic cells based on absorbance at 600 nm using Labsystems Multiskan Ascent microplate reader was determined. Biofilm was measured by discarding the media in the wells, rinsing the well three times with water, and staining the bound cells with crystal violet. The dye was then solubilized with 33% acetic acid, and absorbance at 630 nm was determined using a microtiter plate reader. A composition, comprising sodium citrate, EDTA and zinc chloride showed an enhanced inhibitory effect on biofilm fo...

example 2

y Effect of Sodium Citrate, EDTA and Zinc Chloride Alone, and in Combination on Methicillin-Resistant Staphylococcus Pseudintermedius (MRSP) Growth and Biofilm Formation

[0090]An overnight broth culture of methicillin resistant S. pseudintermedius was grown in TSB and used as inoculum. 96-well microplates containing TSB in the absence and the presence of each compound (sodium citrate or EDTA or Zinc chloride) separately and together (Sodium chloride+EDTA+Zinc chloride) were inoculated and incubated at 37° C. for 24 hours. Growth of plaktonic cells based on absorbance at 600 nm using Labsystems Multiskan Ascent microplate reader was determined. Biofilm was measured by discarding the media in the wells, rinsing the well three times with water, and staining the bound cells with crystal violet. The dye was then solubilized with 33% acetic acid, and absorbance at 630 nm was determined using a microtiter plate reader. A composition, comprising sodium citrate, EDTA and zinc chloride showed ...

example 3

y Effect of Sodium Citrate, EDTA, and Zinc Chloride Alone, and in Combination on Pseudomonas aeruginosa Growth and Biofilm Formation

[0091]An overnight broth culture of P. aeruginosa was grown in TSB and used as inoculum. 96-well microplates containing TSB in the absence and the presence of each compound (sodium citrate or EDTA or Zinc chloride) separately and together (Sodium chloride+EDTA+Zinc chloride) were inoculated and incubated at 37° C. for 24 hours. Growth of plaktonic cells based on absorbance at 600 nm using Labsystems Multiskan Ascent microplate reader was determined. Biofilm was measured by discarding the media in the wells, rinsing the well three times with water, and staining the bound cells with crystal violet. The dye was then solubilized with 33% acetic acid, and absorbance at 630 nm was determined using a microtiter plate reader. A composition, comprising sodium citrate, EDTA and zinc chloride showed an enhanced inhibitory effect on biofilm formation, as compared t...

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Abstract

Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 62 / 018,114, entitled “ANTIMICROBIAL-ANTIBIOFILM COMPOSITIONS AND METHODS OF USE THEREOF FOR PERSONAL CARE PRODUCTS” filed on Jun. 27, 2014.FIELD OF THE INVENTION[0002]This invention may relate to methods of using antimicrobial and antibiofilm compositions for personal care products. It further may relate to methods of formulating the compositions comprising chelating agents, zinc salts, antimicrobials and personal care acceptable excipients for applications in personal care products. More particularly, the invention may relate to an efficient method of delivering acceptable formulations containing two or more chelating agents and a zinc salt for personal care.BACKGROUND OF THE INVENTION[0003]Contact lenses are used by an increasing number of people as means of correcting vision and / or compensating for eye abnormalities. Contact lenses usually must be inserted and remo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/44A61K8/362A61K8/27A61K31/198A61K33/30A61K31/194A61K9/00A61Q17/00A01N37/44A01N59/16A01N37/04A61K45/06A61Q3/00
CPCA61K8/44A61K8/362A61K8/27A61K31/198A61K33/30A61K31/194A61K2800/70A61Q17/005A01N37/44A01N59/16A01N37/04A61K45/06A61Q3/00A61K9/0048A61K8/365A61C11/005A61B3/125A61P17/00A61P27/02A61P31/00A61P31/04A61P31/10Y02A50/30A61K2300/00A01N37/36A01N37/14A01N25/04A01N25/30A61L2/16A61L12/08
Inventor GAWANDE, PURUSHOTTAM V.LOVETRI, KARENYAKANDAWALA, NANDADEVAFROEHLICH, GORDMADHYASTHA, SRINIVASA
Owner KANE BIOTECH
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