Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

Inactive Publication Date: 2017-01-26
BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a new invention of extended release injectable formulations that can provide effective and long-lasting protection against parasites in animals. The formulations contain a special compound called an isoxazoline, which works quickly and safely to kill harmful parasites like fleas and ticks. The formulations are also less irritating to the animal's injection site. This invention can provide a better treatment and prevention option for animal parasite infections and infestations.

Problems solved by technology

Likewise, for the purposes of this application, liquid polyethylene glycols (PEGs) that are not co-polymerized with other pharmaceutically acceptable polymers are considered to be a solvent and are not considered to be a pharmaceutically acceptable polymer

Method used

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  • Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
  • Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof
  • Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof

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examples

[0853]The invention is further described by the following non-limiting examples which further illustrate the invention, and are not intended, nor should they be interpreted to, limit the scope of the invention.

formulation examples

[0854]The following extended release injectable formulations were prepared by mixing the following ingredients. Unless indicated otherwise, the concentrations of each component is percent (%) weight per weight (w / w) and MW refers to weight average molecular weight.

example 1

[0855]

Compound of formula (IIc)  26%Medium molecular weight (MMW) PLGA (50:50)   1%Propylene carbonate50.9%Triacetin22.2%BHT0.02%.

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Abstract

This invention relates to extended release injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a pharmaceutically acceptable polymer, and a solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the extended release injectable formulations of the invention to the animal in need thereof.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. Provisional Application No. 62 / 144,871 filed on Apr. 8, 2015, which is herein incorporated by reference.FIELD OF THE INVENTION[0002]The present invention provides extended release injectable formulations comprising at least one isoxazoline active agent, a pharmaceutically acceptable polymer and a solvent; the use of these formulations against parasites (including ectoparasites (e.g., fleas or ticks) and / or endoparasites), and methods for preventing or treating parasitic infections and infestations in animals.BACKGROUND OF THE INVENTION[0003]Animals such as mammals and birds are often susceptible to parasite infestations / infections. These parasites may be ectoparasites, such as fleas, ticks and parasitic flies, and endoparasites such as nematodes and other worms. Domesticated animals, such as cats and dogs, are often infested with one or more of the following ectoparasites:[0004]fleas (e.g. Cteno...

Claims

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Application Information

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IPC IPC(8): A61K31/42A61K9/00
CPCA61K9/0019A61K31/42A61K9/00A61K31/422A61K47/10A61K47/22A61K2300/00A61P33/00A61P33/14A61K47/30
Inventor CADY, SUSAN MANCINICHEIFETZ, PETERGALESKA, IZABELADE FALLOIS, LOIC LE HIR
Owner BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC
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