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Vaccines and methods to treat lyme disease in dogs

a technology for lyme disease and vaccines, applied in the field of veterinary medicine, can solve the problems of not purging the host of spirochetes and overcoming obstacles, and achieve the effect of preventing lyme diseas

Active Publication Date: 2016-03-24
ZOETIS SERVICE LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The vaccine composition induces robust immune responses against Lyme disease, providing improved protection against diverse OspC phylotypes and associated symptoms, with the inclusion of additional antigens offering broader canine disease protection.

Problems solved by technology

Once infection has occurred, however, the drugs may not purge the host of the spirochete, but may only act to control the chronic forms of the disease.
However, at least two obstacles need to be overcome before a successful vaccine can be created.

Method used

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  • Vaccines and methods to treat lyme disease in dogs
  • Vaccines and methods to treat lyme disease in dogs
  • Vaccines and methods to treat lyme disease in dogs

Examples

Experimental program
Comparison scheme
Effect test

example 1

Determination of B. Burgdorferi OspC Phylotypes Associated with Lyme Disease in Dogs

[0093]Adult Ixodes scapularis ticks were collected in southern Rhode Island by flagging. The percentage of ticks infected with B. burgdorferi was determined through direct fluorescent microscopy using standard methods and labeled anti-B. burgdorferi antibody.

[0094]All procedures were conducted in compliance with regulations of the Animal Welfare Act and the dogs were maintained in accordance with Farm Canine Husbandry Standard Operating Procedures. Fifteen purpose-bred dogs of both sexes (7 males, 8 females; 9 to 10 weeks of age; Marshall Bioresources) were assigned identification numbers and divided into four study groups designated as T01 (n=4), T02 (n=4), T03 (n=4) and T04 (n=3). The dogs were fitted with Elizabethan collars and housed in one-over-one condo style cages. One day prior to tick infestation serum was collected from each dog. Dogs in study groups T01, T02, T03 and T04 were infested wit...

example 2

Efficacy of Recombinant Chimeric Borrelia burgdoferi OspC / OspA Vaccines in Dogs

[0105]Thirty dogs, all in good general health, were chosen for the study. Blood samples were collected prior to the initial vaccination. Dogs received one of the following vaccines, as described in Table 2: T01: PBS (control product); T02: ug / ml OspA+30 ug / ml A12CF (SEQ ID NO: 31); T03: 20 ug / ml OspA+30 ug / ml A10CF (SEQ ID NO: 30). (A12CF consists of epitopes from multiple OspC phylotypes, linked together to form a single polypeptide. A10CF also consists of epitopes from multiple OspC phylotypes; its design is similar to that of A12CF.) Dogs were vaccinated twice, at 8 and 11 weeks of age, and then challenged at 14 weeks of age. Following vaccination, dogs were observed for 20 minutes for reactions or abnormalities. Injection sites were observed on Days 1, 2, 3 and 22, 23, 24 for swelling, pain, heat, abscess, drainage, etc. Each dog was fitted with an Elizabethan [E] collar one day prior to placing the t...

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Abstract

The instant invention provides an immunogenic composition comprising an antigenic fragment of OspA protein of Borrelia burgdorferi and a chimeric protein containing antigenic fragments of different phylotypes of OspC protein of Borrelia burgdorferi. Vaccines incorporating the immunogenic composition of the invention, as well as methods of preventing Lyme disease in dogs and / or protecting dogs from Lyme disease using the vaccines are also provided.

Description

FIELD OF THE INVENTION[0001]This invention is in the field of veterinary medicine. More particularly, this invention is in the field of vaccines treating or preventing Lyme disease in dogs.BACKGROUND[0002]Lyme disease is a bacterial infection caused by pathogenic spirochetes of the genus Borrelia. The infection can occur in humans, dogs, deer, mice and other animals, and is transmitted by arthropod vectors, most notably ticks of the genus Ixodes. Borrelia burgdorferi, the most common cause of Lyme disease in North America, was first cultured in 1982. Borrelia are introduced into the host at the site of the tick bite and this is also the location of the initial characteristic skin lesion, erythema chronicum migrans (ECM). In dogs, Lyme disease manifests with arthritis-induced lameness, anorexia, fever, lethargy, lymphadenopathy, and in some cases, fatal glomerulonephritis. A recent study revealed that the percentage of actively infected dogs in endemic areas can be as high as 11%.[00...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07K14/20
CPCC07K14/20A61K39/0225A61K2039/552A61K2039/55505A61K2039/70C07K2319/00
Inventor LOHSE, ROBERT, M.MEEUS, PATRICK, F., M.MILLERSHIP, JASON, J.XU, ZHICHANGMARCONI, RICHARD, THOMASEARNHART, CHRISTOPHER, G.
Owner ZOETIS SERVICE LLC
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