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Immunogenic Treatment Of Cancer

a cancer and immunomodulatory technology, applied in the field of cancer therapy, can solve the problems of cancer inflammatory response in cancer, adverse effect of current cancer treatment success, and cancer risk factors, and achieve the effect of reducing the toxicity of chemotherapeutic agents, and reducing the risk of cancer

Inactive Publication Date: 2014-12-04
IMMODULON THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

The patent text describes a study that shows using a combination of an immunomodulator and ablative irradiation treatment for cancer is better than using just irradiation alone. The results show that the two treatments work together to make a synergistic effect.

Problems solved by technology

This patent discusses how researchers are trying to improve immunotherapy for cancer patients by breaking immunological tolerances and promoting effective immunity. One way to achieve this is through the use of chemicals called damaging agents, like heat shock proteins, that trigger inflammation and help fight cancer. Another method involves combining ablative and chemotherapies, where the two techniques work together to better target tumors. However, current methods still face challenges related to identifying optimal combinations of drugs and dosages needed for safe and effective treatment.

Method used

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  • Immunogenic Treatment Of Cancer

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example 1

[0081]To investigate the invention, we conducted a study in female Balb / c mice injected subcutaneously with an inoculum of Renca tumour cells and treated with irradiation therapy in combination with IMM-101 (Mycobacterium obuense, rough strain, heat-killed).

[0082]Briefly, adult mice were maintained under SPF conditions at controlled temperature (23±2° C.), Humidity (45±10%) and photoperiod (12 hr light / 12 hr dark). They were provided with water and food at libitum. Mice were individually tagged for identity. At day 0, mice received subcutaneously an inoculum of 105 Renca tumour cell in a 0.2 ml volume of RPMI 1640 medium in their right flank. Tumour establishment and growth was monitored daily. Once tumours became palpable (100-200 mm3 on day 25) mice were randomised and divided into three groups. Group 1 was left untreated. Group 2 and 3 received the following treatments: Group 2) two cycles of one irradiation of the tumour at 2Gy / day every two days for a total of three irradiation...

example 2

[0085]An investigative study of a preparation of heat-killed whole cell M. obuense (IMM-101) in combination with radiation-induced immunogenic tumour necrosis in patients with previously treated colorectal cancer was conducted in patients according to the protocol described in Table 1. Patients were subjected to a dose of M. obuense IMM-101 on the same day as establishment of the baseline and insertion of the fudicial seeds required for correct focusing of cyberknife energy; subsequent SBRT using cyberknife technology to induce tumour necrosis was administered at day 14, together with a further dose of M. obuense (IMM-101). The patients received a further dose of M. obuense (IMM-101) on day 28 and then continued to receive M. obuense (IMM-101) doses at fortnightly intervals between week 8 and 12, inclusively, whereupon the dose frequency was reduced to monthly throughout the remaining period of the year-long study. Patients were then assessed for tumour regression and disease stabil...

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Abstract

The present invention provides an immunomodulator for use in the treatment and/or control of a neoplastic disease in a patient intended to undergo immunogenic cell death therapy simultaneously, separately or sequentially with administration of the immunomodulator. The therapy can be selected from microwave irradiation, targeted radiotherapy, embolization, cryotherapy, ultrasound, high intensity focused ultrasound, cyberknife, hyperthermia, radiofrequency ablation, cryoablation, electrotome heating, hot water injection, alcohol injection, embolization, radiation exposure, photodynamic therapy, laser beam irradiation, and combinations thereof.

Description

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Claims

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Application Information

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Owner IMMODULON THERAPEUTICS
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