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Method of using cytokine assay to diagnose, treat, and evaluate inflammatory and autoimmune diseases

a cytokine assay and cytokine technology, applied in the field of chronic inflammatory diseases, can solve the problems of establishing a definitive link between cytokine expression and diagnosis, prognosis, and prescription of these expensive, powerful and potentially dangerous therapeutic agents

Inactive Publication Date: 2009-12-31
THE BOARD OF RGT UNIV OF OKLAHOMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, despite the advances in pharmaceutical technology, physicians still prescribe these expensive, powerful and potentially dangerous therapeutic agents with no indication of whether patients have the specific inflammatory mediator antagonized by the pharmaceutical, or whether patients will positively respond to the medications.
Thus, despite the need to identify cytokine associations with various inflammatory diseases, there has yet to be established a definitive link between cytokine expression and diagnosis, prognosis, and treatment response of such pathologic states.

Method used

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  • Method of using cytokine assay to diagnose, treat, and evaluate inflammatory and autoimmune diseases
  • Method of using cytokine assay to diagnose, treat, and evaluate inflammatory and autoimmune diseases
  • Method of using cytokine assay to diagnose, treat, and evaluate inflammatory and autoimmune diseases

Examples

Experimental program
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Effect test

example 1

Distinct Cytokine Patterns in Ankylosing Spondylitis (AS)

[0461]A distinct profile of cytokines was generated from patients with ankylosing spondylitis (AS). This cytokine profile was determined by sampling peripheral blood serum for the presence of cytokines. Patients were found to have predictive molecular cytokine profiles based on clinical disease phenotype and disease severity. Specifically, cytokines were found to be similar within the specific disease classifications, but the levels of cytokines were somewhat heterogeneous with regard to individual patient, raising the possibility that various stages of disease and disease severity may be distinguished by this molecular diagnostic mechanism.

[0462]1. Study Population

[0463]Peripheral blood serum was obtained from more than 44 patients with active ankylosing spondylitis who fulfilled the diagnostic criteria and classification by the European Spondylarthropathy Study Group (ESSG)—Bath Criteria (Calin, A., J. D. Taurog., Eds. 1998,...

example 2

Distinct Cytokine Patterns in Psoriatic Arthritis (PsA)

[0476]A distinct profile of cytokines was geneated from patients with psoriatic arthritis (PsA). This distinct cytokine profile was determined by sampling serum and cerebrospinal fluid for the presence of cytokines. Patients were found to have predictive molecular cytoline profiles based on clinical disease phenotype and disease severity. Specifically, cytokines were found to be similar within the specific disease classifications, but the levels of cytokines were somewhat heterogeneous with regard to individual patient, raising the possibility that various stages of disease and disease severity may be distinguished by this molecular diagnostic mechanism.

[0477]1. Study Population

[0478]Peripheral blood serum from seventy-two (72) patients diagnosed with psoriatic arthritis were analyzed. Cerebrospinal fluid from one patient was also analyzed.

[0479]2. Cytokine Measurement

[0480]The samples were analyzed using a comprehensive biometr...

example 3

Distinct Cytokine Patterns in Reactive Arthritis (ReA)

[0487]A distinct profile of cytokines was produced from patients with reactive arthritis (ReA). This distinct cytokine profile was determined by sampling serum for the presence of cytokies. Patients were found to have predictive molecular cytokine profiles based on clinical disease phenotype and disease severity. Specifically, cytokines were found to be similar within the specific disease classifications, but the levels of cytokines were somewhat heterogeneous with regard to individual patient, raising the possibility that various stages of disease and disease severity may be distinguished by this molecular diagnostic mechanism.

[0488]1. Study Population

[0489]Peripheral blood serum from 13 patients diagnosed with reactive arthritis were analyzed.

[0490]2. Cytokine Measurement

[0491]The samples were analyzed using a comprehensive biometric multiplex cytoline assay (BioSource, Camarillo, Calif., USA) (described above).

[0492]3. Statist...

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Abstract

The invention provides methods for diagnosing, treating, or evaluating inflammatory and autoimmune diseases by sampling peripheral blood, serum, plasma, tissue, cerebrospinal fluit, or other bodily fluids from a human subject having a suspected diagnosis. The sample is analyzed for the presence and amount of certain cytokines, which provides the diagnosis, prognosis or evaluation of therapeutic response.

Description

PRIORITY CLAIMS[0001]The present application claims priority to U.S. Provisional Application Ser. No. 60 / 503,131, filed Sep. 15, 2003, the entire contents of which are hereby incorporated by reference.STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY-SPONSORED RESEARCH AND DEVELOPMENT[0002]This invention was made with support from the National Institutes of Health, grant numbers 1P20RR16478 and 1P20RR15577. The Government has certain rights in this invention.BACKGROUND OF THE INVENTION[0003]A. Field of the Invention[0004]The invention relates generally to inflammatory, infectious, and autoimmune disorders. More particularly the invention relates to chronic inflammatory disease. An implementation of the invention relates to the diagnosis, prognosis, evaluation, or treatment response of a disease such as spondyloarthropathy, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, enteropathic arthritis, ulcerative colitis, Crohn's disease, irritable bowel disease, rhe...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68C12Q1/02G01N33/00C40B30/00G01N33/53G01N33/68
CPCG01N33/564G01N33/6863G01N2800/52G01N2800/24G01N2800/104
Inventor CHAPPELL, CHERIE M.CENTOLA, MICHAEL B.ALEX, PHILIP J.HENSLEY, KENNETH
Owner THE BOARD OF RGT UNIV OF OKLAHOMA
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