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Treating rhinitis by topically administering an epinastine solution to the nasal mucous membrane

a technology of epinastine and nasal mucous membrane, which is applied in the field of treating rhinitis by topically administering aqueous solutions containing epinastine, and can solve the problems of ocular and nasal allergic reactions

Inactive Publication Date: 2007-08-09
TRACH VOLKER +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

Significantly reduces eosinophil and neutrophil content in the conjunctiva, inhibits mast cell degranulation, and prolongs the duration of action by approximately 35%, as demonstrated in passive ocular anaphylaxis models in rats.

Problems solved by technology

Moreover, ocular and nasal allergic reactions may be due to the release of other mast cell mediators as well as toxic eosinophilic granule proteins and enzymes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

embodiment

DESCRIPTION OF EMBODIMENT

[0010] 72 hours after the rats have been sensitized by injecting antiserum into the eyelids of the test animals, a fresh provocation was induced in them by intravenous administration of ovalbumin. Some of the experimental animals were pretreated by the administration of solution containing epinastine according to the invention into the conjunctival sac 15 minutes before the ovalbumin is administered. Two hours after the administration of ovalbumin the experimental animals were killed and the conjunctiva was investigated for its content of eosinophils and neutrophils and the mast cell granulation was determined.

Results

[0011] The animals pretreated with epinastine solution according to the invention (0.05-0.5%) had a significantly lower content of eosinophils in their conjunctiva. The animals pretreated with epinastine solution according to the invention had a significantly lower content of lymphocytes in their conjunctiva (p<0.01). In the animals pretreate...

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Abstract

A method for treating allergic rhinitis, comprising topically administering to the nasal mucus membrane of a host in need of such treatment a solution comprising: epinastine, optionally in the form of its racemate, its enantiomers, or its pharmacologically acceptable acid addition salts, in a pharmacologically acceptable carrier.

Description

RELATED APPLICATIONS [0001] This application is a continuation of U.S. Ser. No. 10 / 271,180, filed Oct. 15, 2002, which is a continuation of U.S. Ser. No. 09 / 706,650, filed Nov. 6, 2000, now abandoned, which claims priority to German Application No. 199 54 516.2, filed Nov. 12, 1999, and claims benefit of U.S. Provisional Application Ser. No. 60 / 167,771, filed on Nov. 29, 1999, each of which is hereby incorporated by reference.FIELD OF THE INVENTION [0002] The invention relates to topically administered aqueous solutions containing epinastine, optionally in the form of its racemates, its enantiomers, and optionally in the form of the pharmacologically acceptable acid addition salts thereof. BACKGROUND OF THE INVENTION [0003] Allergic reactions of the eye (hereinafter referred to as ocular allergic reactions) signifies a series of differently defined syndromes. The following are examples of ocular allergic reactions, e.g., seasonal allergic conjunctivitis, perennial allergic conjuncti...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/55A61K9/08F01L9/20A61K9/00A61P27/02A61P27/16A61P37/08A61P43/00H01F7/18H02K33/04
CPCA61K9/0043Y10S514/912A61K31/55A61K9/0048Y10T137/0318A61P11/00A61P11/02A61P27/00A61P27/02A61P27/14A61P27/16A61P37/08A61P43/00F01L9/20
Inventor TRACH, VOLKERDUSCHLER, GEROLD
Owner TRACH VOLKER
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