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Detection of antidepressant induced mania

a technology of antidepressant and mania, which is applied in the field of diagnosis of patient susceptibility to antidepressant-induced mania, can solve the problems of affecting the risk of developing manic switch

Inactive Publication Date: 2006-12-21
CENT FOR ADDICTION & MENTAL HEALTH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method and kit for determining a patient's susceptibility to antidepressant-induced mania by testing for a specific DNA sequence variant in the serotonin transporter gene called the s variant. This information can help healthcare professionals better understand a patient's risk for manic switches and make informed treatment decisions.

Problems solved by technology

In BP patients the switch rate during antidepressant treatment is definitively higher than in UP patients (12) and represents a critical issue for the long-term management of the disorder.
Whether the type of antidepressant treatment can affect the risk of developing manic switches remains controversial.
Investigation for the possible involvement of the 5HTTLPR in the pathogenesis of BP, applying different methods, has lead to conflicting results.

Method used

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  • Detection of antidepressant induced mania
  • Detection of antidepressant induced mania

Examples

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Example 1

Subjects and Methods

Subjects

[0035] The subjects investigated for the purpose of this study have been selected from a larger sample of 300 Bipolar I or Bipolar II patients recruited from hospital clinics and newspaper advertisements in Toronto and across Central Canada, within the research protocols of our group. To all these patients the diagnostic structured interview for DSM-IV Axis I diagnoses (SCID-I) (41) and the Family Interview for Genetic Studies (FIGS) (42) had been administered by trained interviewers. From all patients and their parents, written informed consent to participate in the studies was obtained.

[0036] The SCID-I, the FIGS, the clinical and the life charts available, and also all the information about the past and the current pharmacological treatment recorded during the interviews were blindly and independently reviewed by two trained psychiatrists (E. M., J. L. K.). To avoid investigators' biases, only information and life charts that existed bef...

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Abstract

Methods and kits for assessing the susceptibility of a patient to antidepressant-induced mania are described. The method involves testing a sample from a patient for the presence of the s variant of the 5HTTLPR polymorphism in the 5HTT gene. The presence of this s variant indicates that the patient is more susceptible to antidepressant-induced mania.

Description

[0001] This application is a continuation of U.S. patent application Ser. No. 10 / 075,249, filed Feb. 15, 2002, which claims the benefit under 35 USC §119(e) from U.S. provisional patent application No. 60 / 268,918, filed Feb. 16, 2001 and U.S. provisional patent application No. 60 / 287,128, filed Apr. 30, 2001.FIELD OF THE INVENTION [0002] The present invention relates to methods and kits for determining the susceptibility of a patient to antidepressant-induced mania. BACKGROUND OF THE INVENTION [0003] The induction of mania in patients treated with antidepressants is a complex and not rare phenomenon, which has been described to occur with different frequencies in Bipolar Disorder (BP), Unipolar Disorder (UP), and Obsessive-Compulsive Disorder (OCD) (1-8). In Mood Disorder (MD) patients, the frequency of induction of mania during antidepressant treatment has been estimated to be 9.5-33%, varying in the different studies including different diagnoses (i.e. UP and BP) and different ant...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68C12P19/34
CPCC12Q2600/156C12Q1/6883
Inventor MUNDO, EMANUELAKENNEDY, JAMES
Owner CENT FOR ADDICTION & MENTAL HEALTH
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