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Cleaning of system for dispensing of liquid droplets

a technology for liquid droplets and dispensing systems, which is applied in the direction of immunoassays, instruments, material testing goods, etc., can solve the problems of contamination of the proportion of dispensing systems, and achieve the effects of short washing cycle, enhanced instrument productivity, and reduced carryover

Inactive Publication Date: 2006-11-16
ALLEGRO RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0018] It is an objective to provide a method and system for cleaning a dispenser which dispenses at a volume of 100 μl and below. The present invention is directed towards the provision of a low volume dispensing system that could minimise carryover and yet could operate with relatively short washing cycle so that the productivity of the instrument is enhanced. It would be further advantageous to have such instrument capable of operating in the aspirate-dispense mode so that the sample liquid is collected through the nozzle of the instrument.
[0019] The objective of the present invention is to provide a dispensing device that can operate with reduced carryover in low volume liquid dispensing at the volume of 100 μl and below. It is the further objective to provide a dispensing device that is capable of operating in the aspirate-dispense mode so that the sample liquid is collected through the nozzle of the instrument and which operates with reduced carryover. The second objective is to provide a device and method for minimising the washing time of a dispensing device so that the productivity of the instrument is enhanced. SUMMARY OF THE INVENTION
[0023] Various pressure sources for both air pressure and liquid pressure may be provided and valving may be used to provide the desired effect.

Problems solved by technology

Portion of these dispensers can be contaminated by a liquid used in the dispenser, whether it be sample liquid or system liquid or a mixture of both where a dispensing assembly uses system liquid.

Method used

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  • Cleaning of system for dispensing of liquid droplets
  • Cleaning of system for dispensing of liquid droplets
  • Cleaning of system for dispensing of liquid droplets

Examples

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Embodiment Construction

[0029]FIG. 1 shows a dispensing assembly for dispensing and aspiration of low volumes of liquids, indicated generally by the reference numeral 1, hereinafter, for brevity, the system 1. The system 1 has a dispensing tip 2 terminating in a nozzle 3 that can be connected to an output 4 of a pneumatic source 5 delineated by interrupted lines. The pneumatic source 5 comprises a pressure source 6 and a vacuum source 7 provided by a compressor, not shown. The pneumatic source 5 connects the pressure source 6 and vacuum source 7 via a switching valve 10 to a conduit 11. The conduit 11 in turn feeds, via a switching valve 15, a pneumatic line 16 which in turn feeds a valve 17. The valve 17 is connected to a liquid feed line 18 terminating at an inlet 19 mounted in a cleaning liquid tank or flush bottle 20. The valve 17 also feeds a pneumatic line 21 connected to the dispensing tip 2.

[0030] The dispensing tip 2 houses a valve 25. The valve 15 is also connected to a further pressurising line...

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PUM

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Abstract

There is provided a method of cleaning a dispensing assembly for small liquid droplets less than 50 μl and even as low as 10 nl. A purging step with pressurised gas followed by a cleaning step using a suitable cleaning liquid is carried out a number of times.

Description

INTRODUCTION [0001] The present invention relates to the cleaning, operation and construction of a dispensing assembly for liquid droplets of the order of 50 μl in volume and as low as 10 nl (10−8 I) or even smaller. Further the invention is directed towards providing a method for dispensing such droplets with reduced carryover, namely, the leaving of traces of a sample liquid in a dispenser after the dispenser has been emptied which then mix with the future sample liquids. Further, the invention provides a method and apparatus for cleaning a low volume dispensing system and a dispensing system including a cleaning system. PRIOR ART [0002] The present invention relates to an assembly for dispensing and aspirating small volumes of liquid as used extensively for drug development in the pharmaceutical industry, and also in medical diagnostics, biotechnology and indeed small droplets of liquids as used for many techniques in industry. Particular examples of this are High Throughput Scre...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): B01L3/02
CPCB01L3/021Y10T436/114998B01L99/00G01N35/1004B01L3/0241B01L13/02
Inventor SHVETS, IGORFRANKEN, CECILIAGALLAGHER, AOIFEOSING, JEURGEN
Owner ALLEGRO RES
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