Nuclear matrix protein fluid assay
a nuclear matrix protein and fluid assay technology, applied in the field of body fluidsoluble nuclear matrix proteins as cellular markers, can solve the problems of difficult interpretation of biochemical assessments of cell or tissue viability, especially in the early stages of a malignancy, etc., and achieve the effect of increasing the level of soluble nuclear matrix proteins, reducing the level of these proteins detected, and monitoring the efficacy
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In the description which follows, the generalized method for monitoring cell death by quantitating the body fluid-soluble interior nuclear matrix proteins released from cells into a fluid is disclosed. The method involves the selection of interior nuclear matrix proteins to form a substantially pure preparation of interior nuclear matrix proteins, herein referred to as a NM preparation, and the use of this preparation to generate nuclear matrix protein-specific antibodies. Preferably the antibodies are cell-type specific. The antibodies also may be cell death-type specific. Next, methods are disclosed for designing assays useful for monitoring cell death with these antibodies in different fluid assays, including serum. Methods also are disclosed for inducing the release of these proteins in soluble form from cells.
Biologically relevant mechanisms of cell death generally are classified as either apoptosis or necrosis, primarily on the basis of histological studies. The two mechani...
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